PROCESS FOR THE SYNTHESIS OF MOSAPRIDE - RICHTER GEDEON VEGYESZET

Title:

PROCESS FOR THE SYNTHESIS OF MOSAPRIDE

Document Type and Number:

WIPO Patent Application WO2003106440

Kind Code:

A3

Abstract:

The invention relates to a process for the synthesis of mosapride citrate of formula (I): (R,S)-4-amino-5-chloro-2-ethoxy-N-{ [4-(4-fluoro-benzyl)-2- morpholinyl]-methyl}benzamide citrate dihydrate.

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Inventors:

VUKICS KRISZTINA (HU)
FISCHER JANOS (HU)
LEVAI SANDOR (HU)
ERDELYI PETER (HU)

Application Number:

PCT/HU2003/000042

Publication Date:

June 17, 2004

Filing Date:

June 12, 2003

Export Citation:

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Assignee:

RICHTER GEDEON VEGYESZET (HU)
VUKICS KRISZTINA (HU)
FISCHER JANOS (HU)
LEVAI SANDOR (HU)
ERDELYI PETER (HU)

International Classes:

C07D265/30; (IPC1-7): C07D265/30

Domestic Patent References:

WO1996034851A1

1996-11-07

Foreign References:

EP0243959A1	1987-11-04
EP0640601A1	1995-03-01

Other References:

KATO S ET AL: "NOVEL BENZAMIDES AS SELECTIVE AND POTENT GASTROKINETIC AGENTS 2. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-AMINO-5-CHLORO-2-ETHOXY-N-4-(4-FLUOROBENZYL)-2-MORPHOLINYL METHYLBENZAMIDE CITRATE (AS-4370) AND RELATED COMPOUNDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 34, no. 2, February 1991 (1991-02-01), pages 616 - 624, XP001037842, ISSN: 0022-2623

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