Title:
PROCESS FOR THE SYNTHESIS OF PERGOLIDE
Document Type and Number:
WIPO Patent Application WO2003078432
Kind Code:
A3
Abstract:
A process for the synthesis of pergolide (Formula(I)) (D-6-n-propyl-8betamethylmercaptomethylergo line) from acid 9,10-dihydrolysergic is herein disclosed. The process can be carried out without isolating most intermediates and is particularly convenient both from the yield and safety standpoint. Moreover, pergolide thereby obtained is highly pure and can be conveniently transformed into pergolide mesylate.
Inventors:
CABRI WALTER (IT)
PAISSONI PAOLO (IT)
ROLETTO JACOPO (IT)
FONTE PIERA (IT)
OLMO SARA (IT)
PAISSONI PAOLO (IT)
ROLETTO JACOPO (IT)
FONTE PIERA (IT)
OLMO SARA (IT)
Application Number:
PCT/EP2003/002423
Publication Date:
January 15, 2004
Filing Date:
March 10, 2003
Export Citation:
Assignee:
ANTIBIOTICOS SPA (IT)
CABRI WALTER (IT)
PAISSONI PAOLO (IT)
ROLETTO JACOPO (IT)
FONTE PIERA (IT)
OLMO SARA (IT)
CABRI WALTER (IT)
PAISSONI PAOLO (IT)
ROLETTO JACOPO (IT)
FONTE PIERA (IT)
OLMO SARA (IT)
International Classes:
C07D457/02; C07D457/04; C07D471/04; (IPC1-7): C07D457/02; C07D457/04
Domestic Patent References:
| WO2000044748A1 | 2000-08-03 |
Foreign References:
| EP0571202A1 | 1993-11-24 | |||
| CZ287962B6 | 2001-03-14 | |||
| EP0026671A1 | 1981-04-08 | |||
| US4166182A | 1979-08-28 | |||
| US3901894A | 1975-08-26 |
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