PROCESS FOR SYNTHESIZING 4-SUBSTITUTED AZETIDINONE DERIVATIVE

Title:

PROCESS FOR SYNTHESIZING 4-SUBSTITUTED AZETIDINONE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1994/018163

Kind Code:

A1

Abstract:

The invention relates to a process for synthesizing a 4-substituted azetidinone derivative represented by the general formula (3) (wherein OR1 represents a protected hydroxyl group; CO2R3 represents an esterified carboxyl group; and X and Y represent each independently alkyl, alkenyl, aralkyl, aryl, alkylthio, alkoxy, heterocycle, acyl, amino, hydrogen or halogen, or alternatively X and Y are combined together to represent cycloalkan-2-on-2-yl) by the reaction of an azetidinone derivative represented by general formula (1) (wherein OR1 is as defined above; and R2 represents alkyl, alkenyl or aryl) with an ester compound represented by general formula (2): (wherein CO2R3, X and Y are each as defined above) in the presence of zinc and copper compounds. The invention relates also to a compound represented by general formula (3) and further to a compound prepared by decarboxylating the compound (3), both being useful as an intermediate for synthesizing antibacterial carbapenem compounds.

Inventors:

ISHIGURO MASAJI (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)

Application Number:

PCT/JP1994/000195

Publication Date:

August 18, 1994

Filing Date:

February 10, 1994

Export Citation:

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Assignee:

SUNTORY LTD (JP)
ISHIGURO MASAJI (JP)
NAKATSUKA TAKASHI (JP)
TANAKA RIE (JP)
SHIMAMOTO TETSUO (JP)
YOSHIDA TAKURO (JP)

International Classes:

C07D205/08; (IPC1-7): C07D205/08

Foreign References:

JPS56150058A	1981-11-20
JPS56154458A	1981-11-30
JPS5946265A	1984-03-15
JPS61165365A	1986-07-26
JPS62246550A	1987-10-27

Other References: