Title:
PROCESSES AND INTERMEDIATES FOR PREPARING α,ω-DICARBOXYLIC ACID-TERMINATED DIALKANE ETHERS
Document Type and Number:
WIPO Patent Application WO/2016/077832
Kind Code:
A3
Abstract:
The present disclosure provides a process for the preparation of compounds of formula (III), compounds of formula (V), and corresponding salts of formula (IV). The compounds made by the methods and processes of the invention are particularly useful for administration in humans and animals.
Inventors:
ONICIU CARMEN DANIELA (FR)
GEOFFROY OTTO JOSEPH (US)
GEOFFROY OTTO JOSEPH (US)
Application Number:
PCT/US2015/060917
Publication Date:
July 07, 2016
Filing Date:
November 16, 2015
Export Citation:
Assignee:
GEMPHIRE THERAPEUTICS INC (US)
International Classes:
C07C69/708; C07C41/24; C07C51/09; C07C51/347; C07C59/305; C07C67/303
Domestic Patent References:
| WO2013084237A1 | 2013-06-13 |
Foreign References:
| US5648387A | 1997-07-15 |
Other References:
R.MUELLER ET AL: "Long Hydrocarbon Chain Ether Diols and Ether Diacids That Favorably Alter Lipid Disorder in Vivo", J.MED.CHEM, vol. 47, 2004, pages 5183 - 5197, XP002753203
R.GLEITER ET AL: "Synthesis of 5,5,10,10-Tetramethyl-1-oxacyclotridecane-6,7,8,9-tetrone", LIEBIGS ANN., 1995, pages 1655 - 1661, XP002753204
R. GÓMEZ-BOMBARELLI ET AL: "Mechanism of lactone hydrolysis in neutral and alkaline conditions", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 78, 2013, pages 6868 - 6879, XP002756931
E.WEBER: "Neutraliganden mit Tensidstruktur", LIEBIGS ANN. CHEM., 1983, pages 770 - 801, XP002756932
R.GLEITER ET AL: "Synthesis of 5,5,10,10-Tetramethyl-1-oxacyclotridecane-6,7,8,9-tetrone", LIEBIGS ANN., 1995, pages 1655 - 1661, XP002753204
R. GÓMEZ-BOMBARELLI ET AL: "Mechanism of lactone hydrolysis in neutral and alkaline conditions", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 78, 2013, pages 6868 - 6879, XP002756931
E.WEBER: "Neutraliganden mit Tensidstruktur", LIEBIGS ANN. CHEM., 1983, pages 770 - 801, XP002756932
Attorney, Agent or Firm:
BOTT, Cynthia, M. (LLP350 East Michigan Ave., Suite 30, Kalamazoo MI, US)
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