Title:
PROCESSES FOR THE PREPARATION OF 4(5)-AMINO-5(4)-CARBOXAMIDOIMIDAZOLES AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/021592
Kind Code:
A1
Abstract:
The invention provides novel processes for preparing efficiently compounds of general formula (I) (wherein R¿1? and R¿2? are each independently hydrogen, optionally substituted C¿1?-C¿10? alkyl, C¿3?-C¿14? hydrocarbyl bearing an alicyclic skeleton, or the like) and intermediates thereof. Compounds of general formula (I) can be prepared by subjecting compounds of general formula (II) and/or salts thereof to cyclization hydrolysis in an aqueous basic solution. Further, compounds of general formula (II) can be prepared from industrially easily available diaminomaleonitrile in a high yield.
Inventors:
SHIBASAKI HIROAKI (JP)
NAGASAKI FUMIHIKO (JP)
TAKASE MITSURU (JP)
YAMAZAKI SATORU (JP)
ISHII YUTAKA (JP)
OOHATA KIMIHIKO (JP)
NAGASAKI FUMIHIKO (JP)
TAKASE MITSURU (JP)
YAMAZAKI SATORU (JP)
ISHII YUTAKA (JP)
OOHATA KIMIHIKO (JP)
Application Number:
PCT/JP2000/006397
Publication Date:
March 29, 2001
Filing Date:
September 20, 2000
Export Citation:
Assignee:
NIPPON SODA CO (JP)
IBARAKI KASEI CO LTD (JP)
SHIBASAKI HIROAKI (JP)
NAGASAKI FUMIHIKO (JP)
TAKASE MITSURU (JP)
YAMAZAKI SATORU (JP)
ISHII YUTAKA (JP)
OHATA KIMIHIKO (JP)
IBARAKI KASEI CO LTD (JP)
SHIBASAKI HIROAKI (JP)
NAGASAKI FUMIHIKO (JP)
TAKASE MITSURU (JP)
YAMAZAKI SATORU (JP)
ISHII YUTAKA (JP)
OHATA KIMIHIKO (JP)
International Classes:
C07C257/14; C07D233/70; C07D233/90; (IPC1-7): C07D233/90; C07C257/14
Foreign References:
US3778446A | 1973-12-11 | |||
JPS5119127A | 1976-02-16 |
Other References:
ALVES M.J. ET AL.: "Synthesis of 4- and 5-disubstituted 1-benzylimidazoles, important precursors of purine analogs", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 31, no. 2, 1994, pages 345 - 350, XP002935196
BOOTH B.L. ET AL.: "Synthesis of (1alpha,2beta,3alpha)-5-amino-(2,3-bis(benzoyloxymethyl)cyclobutyl)imidazoles", TETRAHEDRON LETTERS, vol. 34, no. 34, 1993, pages 5503 - 5506, XP002935197
BOOTH B.L. ET AL.: "Synthesis of (1alpha,2beta,3alpha)-5-amino-(2,3-bis(benzoyloxymethyl)cyclobutyl)imidazoles", TETRAHEDRON LETTERS, vol. 34, no. 34, 1993, pages 5503 - 5506, XP002935197
Attorney, Agent or Firm:
Tokai, Yusaku (2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)
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