Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PROCESSES FOR PREPARATION OF TETRAHYDRONAPHTHALENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/042243
Kind Code:
A1
Abstract:
Processes for preparing optically active intermediates for the synthesis of tetrahydronaphthalene derivatives useful as PGI¿2? agonist can be provided by providing a method for optical resolution of a tetrahydronaphthalene derivative of the following general formula with a reagent for optical resolution and a method for inversion of such a derivative at its asymmetric center. In the formula, R?1¿ is a hydroxyl-protecting group; R?2¿ is hydrogen or halogeno; R?3¿ is hydrogen, hydroxyl, or protected hydroxyl; and R?4¿ is hydrogen, hydroxyl, protected hydroxyl, lower alkyl, or halogeno.

Inventors:
Ichihara, Masaharu c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Hashimoto, Norio c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Ohigashi, Atsushi c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Kanda, Atsushi c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Kagara, Kooji c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Moriki, Shigeru c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Baba, Yukihisa c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Application Number:
PCT/JP2001/009861
Publication Date:
May 30, 2002
Filing Date:
November 12, 2001
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
FUJISAWA PHARMACEUTICAL CO., LTD (4-7 Doshomachi 3-chome, Chuo-ku Osaka-shi, Osaka, 541-8514, JP)
Ichihara, Masaharu c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Hashimoto, Norio c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Ohigashi, Atsushi c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Kanda, Atsushi c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Kagara, Kooji c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Moriki, Shigeru c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
Baba, Yukihisa c/o Fujisawa Pharmaceutical Co. (Ltd. 4-7 Doshomachi 3-chom, Chuo-ku Osaka-shi Osaka, 541-8514, JP)
International Classes:
C07B57/00; (IPC1-7): C07B57/00; C07B53/00; C07B55/00; C07C37/01; C07C39/38; C07C41/26; C07C41/32; C07C43/23
Domestic Patent References:
WO2000078350A1
WO1995024393A1
Foreign References:
JPH09187292A
JPH07196565A
JPH04211074A
Other References:
RUANO JOSE L. GARCIA ET AL.: 'A new stereo-controlled entry into the anthracyclinone families. Part 1. Synthesis of bicyclic precursors of 4-demethoxy-7-deoxy-derivatives' TETRAHEDRON ASYMMETRY vol. 10, no. 15, 1999, pages 2935 - 2944, XP004179149
KIM HEE-DOO ET AL.: 'A novel synthetic route to 11-deoxyanthracycline AB synthons' ARCH. PHARMACOL. RES. vol. 17, no. 4, 1994, pages 249 - 255, XP002908284
IZAWA TOSHIO ET AL.: 'A novel enantiocontrolled synthesis of (+)-9-deacetyl-9-(hydroxymethyl)-4-demethox ydaunomycinone' CHEM. LETT. no. 8, 1987, pages 1655 - 1656, XP002908285
COREY E.J. ET AL.: 'Short enantioselective synthesis of (-)-ovalicin, a potent inhibitor of angiogenesis, using substrate-enhanced catalytic asymmetric dihydroxylation' J. AM. CHEM. SOC. vol. 116, no. 26, 1994, pages 12109 - 12110, XP002908286
Attorney, Agent or Firm:
Tabushi, Eiji c/o Fujisawa Pharmaceutical Co. (Ltd. Osaka Factory 1-6 Kashima 2-chom, Yodogawa-ku Osaka-shi Osaka, 532-8514, JP)
Download PDF: