PROCESSES OF PREPARING 3-FLUORO-5- ( ( (1S, 2AR) -1, 3, 3, 4, 4-PENTAFLUORO-2A-HYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) OXY) -BENZONITRILE

Title:

PROCESSES OF PREPARING 3-FLUORO-5- ( ( (1S, 2AR) -1, 3, 3, 4, 4-PENTAFLUORO-2A-HYDROXY-2, 2A, 3, 4-TETRAHYDRO-1H-CYCLOPENTA [CD] INDEN-7-YL) OXY) -BENZONITRILE

Document Type and Number:

WIPO Patent Application WO/2022/082329

Kind Code:

A1

Abstract:

Disclosed herein are processes for preparing 3-fluoro-5-(((1S,2aR)-1,3,3,4,4- pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile (hereinafter as compound (I) having the following structure).

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Inventors:

SHI YUETAO (CN)
FU JIPING (US)
LOU YAN (US)
HE YIGANG (US)
ZHOU PENG (CN)
LI XINGXING (CN)

Application Number:

PCT/CN2020/121745

Publication Date:

April 28, 2022

Filing Date:

October 19, 2020

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Assignee:

NIKANG THERAPEUTICS INC (US)

International Classes:

C07C255/54; C07C29/143; C07C35/37; C07C41/24; C07C43/295; C07C45/40; C07C49/513; C07C253/30

Domestic Patent References:

WO2020081695A1	2020-04-23
WO2018031680A1	2018-02-15
WO2016057242A1	2016-04-14
WO2016145032A1	2016-09-15
WO2016168510A1	2016-10-20
WO2019191227A1	2019-10-03
WO2017053192A1	2017-03-30

Foreign References:

CN105530923A	2016-04-27
US20160362390A1	2016-12-15

Attorney, Agent or Firm:

CHINA PATENT AGENT (H.K.) LTD. (CN)

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