Title:
PROCESSES FOR PREPARING OPTICALLY ACTIVE AMINO ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/060795
Kind Code:
A1
Abstract:
An optically active amino acid derivative is prepared either by subjecting an optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3-haloalanine derivative to N-protection to obtain an optically active 3-haloalanine derivative (4) whose amino group is protected with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R?1¿ and R?2¿ are each hydrogen or the like; ?*¿ represents an asymmetric carbon atom; and P?1¿ is 2- and/ or 4- nitrated benzenesulfonyl.
Inventors:
SUGAWARA MASANOBU (JP)
FUJII AKIO (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
TAKEDA TOSHIHIRO (JP)
KINOSHITA KOICHI (JP)
MOROSHIMA TADASHI (JP)
FUSE YOSHIHIDE (JP)
UEDA YASUYOSHI (JP)
FUJII AKIO (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
TAKEDA TOSHIHIRO (JP)
KINOSHITA KOICHI (JP)
MOROSHIMA TADASHI (JP)
FUSE YOSHIHIDE (JP)
UEDA YASUYOSHI (JP)
Application Number:
PCT/JP2001/001132
Publication Date:
August 23, 2001
Filing Date:
February 16, 2001
Export Citation:
Assignee:
KANEKA CORP (JP)
SUGAWARA MASANOBU (JP)
FUJII AKIO (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
TAKEDA TOSHIHIRO (JP)
KINOSHITA KOICHI (JP)
MOROSHIMA TADASHI (JP)
FUSE YOSHIHIDE (JP)
UEDA YASUYOSHI (JP)
SUGAWARA MASANOBU (JP)
FUJII AKIO (JP)
OKURO KAZUMI (JP)
SAKA YASUHIRO (JP)
NAGASHIMA NOBUO (JP)
INOUE KENJI (JP)
TAKEDA TOSHIHIRO (JP)
KINOSHITA KOICHI (JP)
MOROSHIMA TADASHI (JP)
FUSE YOSHIHIDE (JP)
UEDA YASUYOSHI (JP)
International Classes:
C07C227/10; C07C227/32; C07C227/42; C07C229/30; C07C303/36; C07D203/08; C07D203/20; C07D203/24; C07C229/26; C07C311/19; (IPC1-7): C07D203/08; C07D203/24; C07C227/04; C07C227/10; C07C229/26; C07C311/19; C07B53/00
Domestic Patent References:
| WO1982004043A1 | 1982-11-25 |
Foreign References:
| JPS355474B1 | ||||
| JPS358315B1 | ||||
| JPS57146751A | 1982-09-10 | |||
| GB847205A | 1960-09-07 | |||
| JPS4517420B1 | ||||
| JPS5049227A | 1975-05-01 | |||
| JPH07138281A | 1995-05-30 | |||
| JPH11171860A | 1999-06-29 |
Other References:
CAN. J. CHEM., vol. 76, no. 6, 1998, pages 738 - 750, XP002941611
J. PHYS. ORG. CHEM., vol. 9, no. 6, 1996, pages 341 - 347, XP002941612
See also references of EP 1179530A4
J. PHYS. ORG. CHEM., vol. 9, no. 6, 1996, pages 341 - 347, XP002941612
See also references of EP 1179530A4
Attorney, Agent or Firm:
Oguri, Shohei (28th Floor 12-32, Akasaka 1-chome Minato-ku Tokyo, JP)
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