Title:
PROCESSES FOR PREPARING PEMETREXED DISODIUM AND ITS INTERMEDIATE,4-(4-CARBOMETHOXYPHENYL)BUTANAL
Document Type and Number:
WIPO Patent Application WO/2009/143684
Kind Code:
A1
Abstract:
Disclosed are processes for preparing pemetrexed disodium and its intermediate,4-(4-carbomethoxyphenyl)butanal. The process for preparing the intermediate comprises the following steps: methyl 4-bromobenzoate is condensed with 3-buten-1-ol; organic solvent is used to extract during the post-treatment; silica gel is added to decolorize; and the organic solvent is evaporated to give 4-(4-carbomethoxyphenyl)butanal. The product obtained by the present process, with a yield of higher than 80 %, and a purity measured by GC of higher than 95 %, may be directly used in the next bromination reaction for synthesizing pemetrexed disodium without purification. The present process is suitable for industrial production for the operation is simple and the reagents used are cheap and easy to be obtained.
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Inventors:
LI, Jinliang (No. 1479, Zhang Heng Road Zhangjiang Hi-Tech Park, Pu Dong, Shanghai 3, 201203, CN)
李金亮 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
李金亮 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
Application Number:
CN2008/073182
Publication Date:
December 03, 2009
Filing Date:
November 25, 2008
Export Citation:
Assignee:
SHANGHAI DESANO PHARMACEUTICALS INVESTMENT CO., LTD. (No. 1479, Zhang Heng Road Zhangjiang Hi-Tech Park, Pu Dong, Shanghai 3, 201203, CN)
上海迪赛诺医药投资有限公司 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
SHANGHAI DESANO PHARMACEUTICAL HOLDING CO., LTD. (No. 1479, Zhang Heng Road Zhangjiang Hi-Tech Park, Pu Dong, Shanghai 3, 201203, CN)
上海迪赛诺医药发展有限公司 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
上海迪赛诺医药投资有限公司 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
SHANGHAI DESANO PHARMACEUTICAL HOLDING CO., LTD. (No. 1479, Zhang Heng Road Zhangjiang Hi-Tech Park, Pu Dong, Shanghai 3, 201203, CN)
上海迪赛诺医药发展有限公司 (中国上海市浦东新区张江高科技园区张衡路1479号, Shanghai 3, 201203, CN)
International Classes:
C07C45/46; C07C47/228; C07D487/04
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (XU Xun, 435 Guiping Road Xuhui, Shanghai 3, 200233, CN)
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