PROCESSES FOR PRODUCING ACRYLIC ACID DERIVATIVE

Title:

PROCESSES FOR PRODUCING ACRYLIC ACID DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2000/040537

Kind Code:

A1

Abstract:

Processes for producing a compound (1) represented by formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formylating a compound (3) (step (1)) and the step of converting the OH of the resultant compound (2) into OR' (step (2)). The step (1) comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The step (2) comprises [1] reacting the compound (2) with R' OH or with R' OH and CH(OR')¿3? under acidic conditions or [2] using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another process, the compound (1) is efficiently produced without isolating the compound (2). In still another process, the compound (1) is directly produced without via the compound (2).

Inventors:

MIYAZAWA YASUYUKI (JP)
SAGAE TAKAHIRO (JP)
ISHII HIROSHI (JP)
YAZAKI HIROYUKI (JP)
FUNABORA MAKOTO (JP)
TAKASE MITSURU (JP)
IIYOSHI YOSHIYUKI (JP)
YAMAZAKI SATORU (JP)
KAWAHARA NORIAKI (JP)

Application Number:

PCT/JP1999/007397

Publication Date:

July 13, 2000

Filing Date:

December 28, 1999

Export Citation:

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Assignee:

NIPPON SODA CO (JP)
MIYAZAWA YASUYUKI (JP)
SAGAE TAKAHIRO (JP)
ISHII HIROSHI (JP)
YAZAKI HIROYUKI (JP)
FUNABORA MAKOTO (JP)
TAKASE MITSURU (JP)
IIYOSHI YOSHIYUKI (JP)
YAMAZAKI SATORU (JP)
KAWAHARA NORIAKI (JP)

International Classes:

C07B41/06; C07C67/343; C07D239/52; C07D311/76; (IPC1-7): C07C45/68; C07B37/00; C07B41/04; C07B41/06; C07C45/64; C07C49/248; C07C49/258; C07C67/31; C07C67/343; C07C69/73; C07C69/732; C07C69/734; C07D239/52; C07D311/76; C07F7/18

Domestic Patent References:

WO1995025729A1	1995-09-28
WO1999044969A1	1999-09-10

Foreign References:

EP0278595A2	1988-08-17
JPS5084501A	1975-07-08
EP0754672A1	1997-01-22

Other References: