Title:
PROCESSES FOR PRODUCING ISOTHIAZOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1996/017834
Kind Code:
A1
Abstract:
A process for producing a 1,2-benzisothiazole by the reaction of a 2-(alkylthio)benzaldehyde oxime with a halogen compound; a process for producing a 3-halo-1,2-benzisothiazole by the reaction of a 1,2-benzisothiazole with a halogenating agent; and a process for producing a 1-(1,2-benzisothiazol-3-yl)-piperazine by the reaction of the 3-halo-1,2-benzisothiazole thus obtained with a piperazine. It is possible according to these processes to produce 1,2-benzisothiazoles, 3-halo-1,2-benzisothiazoles and, further therefrom, 1-(1,2-benzisothiazol-3-yl)-piperazines, each being useful as intermediates for medicines such as remedies for mental illness, readily in high yields through shorter process steps without the necessity for using expensive starting materials.
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Inventors:
KAGANO HIROKAZU (JP)
GODA HIROSHI (JP)
YAMAMOTO MIKIO (JP)
SAKAUE SHIGEKI (JP)
TOUDOU MIKI (JP)
GODA HIROSHI (JP)
YAMAMOTO MIKIO (JP)
SAKAUE SHIGEKI (JP)
TOUDOU MIKI (JP)
Application Number:
PCT/JP1995/002484
Publication Date:
June 13, 1996
Filing Date:
December 04, 1995
Export Citation:
Assignee:
SUMITOMO SEIKA CHEMICALS (JP)
KAGANO HIROKAZU (JP)
GODA HIROSHI (JP)
YAMAMOTO MIKIO (JP)
SAKAUE SHIGEKI (JP)
TOUDOU MIKI (JP)
KAGANO HIROKAZU (JP)
GODA HIROSHI (JP)
YAMAMOTO MIKIO (JP)
SAKAUE SHIGEKI (JP)
TOUDOU MIKI (JP)
International Classes:
C07D275/04; (IPC1-7): C07D275/04
Foreign References:
| JPH05201808A | 1993-08-10 | |||
| JPS4843858B1 | 1973-12-21 | |||
| JPS6383067A | 1988-04-13 | |||
| JPS6383085A | 1988-04-13 |
Other References:
See also references of EP 0805151A4
ANN. CHIM. (ROME, vol. 53, no. 5, 1963, pages 577 - 87
SYNTHESIS, no. 1, 1978, pages 58 - 60
GER. OFFEN., 1986, pages 3530089
ANN. CHIM. (ROME, vol. 53, no. 5, 1963, pages 577 - 87
SYNTHESIS, no. 1, 1978, pages 58 - 60
GER. OFFEN., 1986, pages 3530089
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