Title:
PROCOLLAGEN (III) PROPEPTIDES AND RELATED SUBSTANCES FOR TREATING FIBROTIC DISEASES
Document Type and Number:
WIPO Patent Application WO2002036154
Kind Code:
A3
Abstract:
The invention relates to the use of procollagen (III) propeptides and related substances for treating fibrotic diseases and to a method for producing and renaturing recombinant N and/or C-terminal procollagen (III) propeptides. Said procollagen (III) propeptides and related substances are suitable for treating fibrosis of any type, of any organ manifestation. The invention also relates to a method for producing renatured N-terminal procollagen (III) propeptide and/or C-terminal procollagen (III) propeptide.
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Inventors:
BURCHARDT ELMAR R (DE)
Application Number:
PCT/EP2001/012663
Publication Date:
January 30, 2003
Filing Date:
October 31, 2001
Export Citation:
Assignee:
BURCHARDT ELMAR R (DE)
International Classes:
A61P43/00; C07K14/78; A61K38/00; (IPC1-7): A61K38/39; A61P43/00; C07K1/113
Domestic Patent References:
| WO1999061477A2 | 1999-12-02 | |||
| WO1999024835A2 | 1999-05-20 | |||
| WO1997008311A1 | 1997-03-06 | |||
| WO2000027377A2 | 2000-05-18 |
Foreign References:
| EP0304292A2 | 1989-02-22 |
Other References:
KAUSCHKE S. ET AL.: "Two assays for measuring fibrosis : reverse transcriptase-polymerase chain reaction of collagen alpha1 (III) mRNA is an early predictor of subsequent collagen deposition while a novel serum N-terminal procollagen (III) propeptide assay reflects manifest fibrosis in carbon tetrachloride-treated rats.", ANALYTICAL BIOCHEMISTRY., vol. 275, 1999, pages 131 - 140, XP002213793
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