Title:
PRODRUG ACTIVATION OF N-OXIDES BY RADIOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2023/217093
Kind Code:
A1
Abstract:
Provided herein pertains to the biomedical field, and particularly relates to a method for activating N-oxide prodrugs with radiation, and a method of treating or suppressing a cancer, reducing its severity, lowering its risk or inhibiting its metastasis in an individual. The method comprises administering to the individual a therapeutically effective amount of an N-oxide prodrug, and radiating the individual with a therapeutically effective amount of radiotherapy.
Inventors:
LIU ZHIBO (CN)
DING ZEXUAN (CN)
DING ZEXUAN (CN)
Application Number:
PCT/CN2023/092817
Publication Date:
November 16, 2023
Filing Date:
May 08, 2023
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
A61K41/00; A61P35/00
Foreign References:
| CN112168978A | 2021-01-05 | |||
| CN113101372A | 2021-07-13 |
Other References:
DING ZEXUAN, GUO ZHIBIN, ZHENG YUEDAN, WANG ZIYANG, FU QUNFENG, LIU ZHIBO: "Radiotherapy Reduces N -Oxides for Prodrug Activation in Tumors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 144, no. 21, 1 June 2022 (2022-06-01), pages 9458 - 9464, XP093108722, ISSN: 0002-7863, DOI: 10.1021/jacs.2c02521
JUSTIN KIM; CAROLYN R. BERTOZZI: "A Bioorthogonal Reaction of NâOxide and Boron Reagents", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 54, no. 52, 16 November 2015 (2015-11-16), Hoboken, USA, pages 15777 - 15781, XP072080803, ISSN: 1433-7851, DOI: 10.1002/anie.201508861
J E RUSCOE , H JEWELL, J L MAGGS, P M O'NEILL, R C STORR, S A WARD, B K PARK: "The Effect of Chemical Substitution on the Metabolic Activation, Metabolic Detoxication, and Pharmacological Activity of Amodiaquine in the Mouse", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 273, no. 1, 31 December 1995 (1995-12-31), US , pages 393 - 404, XP009550428, ISSN: 0022-3565
KERZIG CHRISTOPH, GUO XINGWEI, WENGER OLIVER S.: "Unexpected Hydrated Electron Source for Preparative Visible-Light Driven Photoredox Catalysis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 5, 6 February 2019 (2019-02-06), pages 2122 - 2127, XP093108883, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12223
JUSTIN KIM; CAROLYN R. BERTOZZI: "A Bioorthogonal Reaction of NâOxide and Boron Reagents", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 54, no. 52, 16 November 2015 (2015-11-16), Hoboken, USA, pages 15777 - 15781, XP072080803, ISSN: 1433-7851, DOI: 10.1002/anie.201508861
J E RUSCOE , H JEWELL, J L MAGGS, P M O'NEILL, R C STORR, S A WARD, B K PARK: "The Effect of Chemical Substitution on the Metabolic Activation, Metabolic Detoxication, and Pharmacological Activity of Amodiaquine in the Mouse", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 273, no. 1, 31 December 1995 (1995-12-31), US , pages 393 - 404, XP009550428, ISSN: 0022-3565
KERZIG CHRISTOPH, GUO XINGWEI, WENGER OLIVER S.: "Unexpected Hydrated Electron Source for Preparative Visible-Light Driven Photoredox Catalysis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 5, 6 February 2019 (2019-02-06), pages 2122 - 2127, XP093108883, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12223
Attorney, Agent or Firm:
LIFANG & PARTNERS et al. (CN)
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