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Title:
PRODRUGS COMPRISING A PYROGLUTAMATE LINKER
Document Type and Number:
WIPO Patent Application WO/2016/196124
Kind Code:
A3
Abstract:
The present invention relates to novel prodrugs of primary or secondary amine-comprising biologically active moieties and pharmaceutically acceptable salts thereof, prodrug reagents, pharmaceutical compositions comprising said prodrugs and the use of prodrugs.

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Inventors:
RAU HARALD (DE)
BISEK NICOLA (DE)
WEISBROD SAMUEL (DE)
Application Number:
PCT/US2016/034105
Publication Date:
January 19, 2017
Filing Date:
May 25, 2016
Export Citation:
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Assignee:
ASCENDIS PHARMA INC (US)
ASCENDIS PHARMA AS (DK)
International Classes:
A61K8/42; A61K8/44; C07K4/00; C07K5/00
Foreign References:
US20130072491A12013-03-21
US20140323402A12014-10-30
Other References:
DATABASE PUBCHEM [o] 20 August 2014 (2014-08-20), XP055437933, Database accession no. 651631
Attorney, Agent or Firm:
TRELOAR, Joseph, W. (US)
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