Title:
PRODRUGS OF DIARYL-2-(5H)-FURANONE CYCLOOXYGENASE-2 INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005042476
Kind Code:
A3
Abstract:
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more soluble in aqueous media than the active agents into which they convert, in vivo. As such compounds of Formula (I) and (II) are advantageous for, among other things intravenous administration. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) and Formula (II).
Inventors:
ARRUDA JEANNIE M (US)
MUNOZ BENITO (US)
STEARNS BRIAN A (US)
MUNOZ BENITO (US)
STEARNS BRIAN A (US)
Application Number:
PCT/US2004/034374
Publication Date:
June 09, 2005
Filing Date:
October 18, 2004
Export Citation:
Assignee:
MERCK & CO INC (US)
ARRUDA JEANNIE M (US)
MUNOZ BENITO (US)
STEARNS BRIAN A (US)
ARRUDA JEANNIE M (US)
MUNOZ BENITO (US)
STEARNS BRIAN A (US)
International Classes:
A61K31/19; A61K31/195; A61K31/215; C07C315/00; C07C317/46; C07C323/00; (IPC1-7): C07C315/00; C07C323/00; A61K31/19; A61K31/215; A61K31/195
Foreign References:
| US5807873A | 1998-09-15 |
Other References:
See also references of EP 1678126A4
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