Title:
PRODRUGS OF KV7 CHANNEL OPENERS
Document Type and Number:
WIPO Patent Application WO/2022/198116
Kind Code:
A8
Abstract:
Prodrugs of pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula (I); or pharmaceutically acceptable salts thereof, where the symbols R1, R2, R3, R4, R5 and R6a, R6b, and R6c and where the symbol Z are defined. Methods for the synthesis, purification, testing and use as prodrugs of pharmacologically-active agents at Kv7 ion channels are provided.
Inventors:
CREAN CHRISTOPHER S (US)
BROWN EDWARD G (US)
BROWN EDWARD G (US)
Application Number:
PCT/US2022/021059
Publication Date:
November 09, 2023
Filing Date:
March 20, 2022
Export Citation:
Assignee:
XYZAGEN INC (US)
International Classes:
C07C271/28; A61K31/216; A61K31/44; A61P21/00; A61P25/08; A61P29/00; C07D213/74
Attorney, Agent or Firm:
FIX, Amy H. (US)
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