Title:
PRODUCT, APPLICATION AND METHOD USED FOR MALIGNANT TUMOUR-RELATED SCREENING AND ASSESSMENT
Document Type and Number:
WIPO Patent Application WO/2017/054686
Kind Code:
A1
Abstract:
A product used for malignant tumour screening, early diagnosis, prognostic assessment, risk assessment, condition monitoring and/or efficacy assessment, an application of a reagent, instrument, module and/or processor in the preparation of the product, and a method used for drug and/or treatment method screening. The product comprises: (A) a reagent, instrument and/or system used for determining the degree of blood IgG surface biantennary complex N-sugar chain terminal galactosylation, determining an IgG surface terminal galactose linkage-free biantennary complex N-sugar chain abundance (Gal0), a terminal single galactose linkage biantennary complex N-sugar chain abundance (Gal1), and a terminal double galactose linkage biantennary complex N-sugar chain abundance (Gal2); (B) a module and/or processor used for calculating a Gal0, Gal1 and Gal2 abundance ratio value (Gal ratio); (C) optionally, a module and/or processor used for determining whether a target is suffering from a malignant tumour, and performing prognostic assessment and/or tumour risk assessment, condition monitoring and/or efficacy assessment on the target according to the Gal ratio.
Inventors:
REN SHIFANG (CN)
GU JIANXIN (CN)
ZHOU LEI (CN)
SUN LINLIN (CN)
GU JIANXIN (CN)
ZHOU LEI (CN)
SUN LINLIN (CN)
Application Number:
PCT/CN2016/100048
Publication Date:
April 06, 2017
Filing Date:
September 26, 2016
Export Citation:
Assignee:
SHANGHAI ZHIXIAN BIOTECHNOLOGY CORP LTD (CN)
International Classes:
G01N33/68
Domestic Patent References:
| WO2009013538A2 | 2009-01-29 |
Foreign References:
| CN105277718A | 2016-01-27 | |||
| CN101074951A | 2007-11-21 | |||
| US20040191256A1 | 2004-09-30 |
Other References:
QIAN, YIFAN ET AL.: "Quantitative Analysis of Serum IgG Galactosylation Assists Differential Diagnosis of Ovarian Cancer", JOURNAL OF PROTEOME RESEARCH, vol. 12, no. 9, 6 September 2013 (2013-09-06), pages 4046 - 4055
KRISTEL, K. ET AL.: "Immunoglobulin G Fc N-Glycan Profiling in Patients with Gastric Cancer by LC-ESI-MS: Relation to Tumor Progression and Survival", GLYCOCONJUGATE JOURNAL, vol. 29, no. 1, 17 December 2011 (2011-12-17), pages 57 - 66, XP035002293
RADKA, S. ET AL.: "Ovarian Cancer is Associated with Changes in Glycosylation in both Acute-Phase Proteins and IgG", GLYCOBIOLOGY, vol. 17, no. 12, 20 September 2007 (2007-09-20), pages 1344 - 1356, XP055372415
KRISTEL, K. ET AL.: "Immunoglobulin G Fc N-Glycan Profiling in Patients with Gastric Cancer by LC-ESI-MS: Relation to Tumor Progression and Survival", GLYCOCONJUGATE JOURNAL, vol. 29, no. 1, 17 December 2011 (2011-12-17), pages 57 - 66, XP035002293
RADKA, S. ET AL.: "Ovarian Cancer is Associated with Changes in Glycosylation in both Acute-Phase Proteins and IgG", GLYCOBIOLOGY, vol. 17, no. 12, 20 September 2007 (2007-09-20), pages 1344 - 1356, XP055372415
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
Download PDF:
Previous Patent: METHODOLOGY TO IMPROVE THE ANOMALY DETECTION RATE
Next Patent: ELECTRIC DRIVE SYSTEM FOR MOTOR VEHICLE AND MOTOR VEHICLE USING SAME
Next Patent: ELECTRIC DRIVE SYSTEM FOR MOTOR VEHICLE AND MOTOR VEHICLE USING SAME