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Title:
MICRO/NANOMATERIAL, PRODUCT THEREOF WITH SURFACE COVALENTLY MODIFIED WITH HYDROPHILIC MATERIAL, AND MANUFACTURING METHOD
Document Type and Number:
WIPO Patent Application WO/2017/211145
Kind Code:
A1
Abstract:
The present invention discloses a micro/nanomaterial, a product thereof with a surface covalently modified with a hydrophilic material, and a manufacturing method. The surface of the micro/nanomaterial comprises a carboxyl group or potential carboxyl group. The carboxyl group or potential carboxyl group is converted to an active ester. The product with the surface covalently modified with the hydrophilic material is covalently modified by forming an amide bond between the active ester on the surface and a modification agent, wherein the modification agent is a hydrophilic compound and/or a hydrophilic polymer comprising a primary aliphatic amine and/or a secondary aliphatic amine. The manufacturing method comprises: using a carboxyl group and/or potential carboxyl group monomer to generate an adequate amount of carboxyl groups and/or potential carboxyl groups on the surface of a polymeric material, then converting to form an active ester; using an adequately sized modification agent comprising a primary and/or secondary aliphatic amine, potential zwitterion group, and hydrophilic spacer arm to form an amide bond to obtain a covalently modified layer; and regenerating the active ester on the surface of a covalently modified product, then using an amide bond formation process to create a multi-layered covalent modification. High performance coating of a surface of a micro/nanomaterial is achieved by using a medium-sized hydrophilic modification agent. A modified product has significantly reduced non-specific absorption of a biomolecule.

Inventors:
LIAO, Fei (Production Service Building, Innovation Productivity Promotion Center Technology 3rd Road, Xiyong,Shapingba District, Chongqing 2, 401332, CN)
LONG, Gaobo (Production Service Building, Innovation Productivity Promotion Center Technology 3rd Road, Xiyong,Shapingba District, Chongqing 2, 401332, CN)
YANG, Hai (Production Service Building, Innovation Productivity Promotion Center Technology 3rd Road, Xiyong,Shapingba District, Chongqing 2, 401332, CN)
FENG, Hu (Production Service Building, Innovation Productivity Promotion Center Technology 3rd Road, Xiyong,Shapingba District, Chongqing 2, 401332, CN)
Application Number:
CN2017/082374
Publication Date:
December 14, 2017
Filing Date:
April 28, 2017
Export Citation:
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Assignee:
CHONGQING FARSIGHTED-BLUE-DRAGON (FBD) BIOTECHNOLOGY CO., LTD., CHINA (Production Service Building, Innovation Productivity Promotion Center Technology 3rd Road, Xiyong,Shapingba District, Chongqing 2, 401332, CN)
International Classes:
C08F290/06; C07C231/12; C07C269/04; C07C271/20; C08F8/32; C08F220/58; C08F222/38; C08G65/332; C08G81/02
Foreign References:
CN106519147A2017-03-22
CN102617810A2012-08-01
Other References:
ZHAI, YUNHUI ET AL.: "Preparation of composite magnetic microspheres containing carboxyl and amine", NEW CHEMICAL MATERIALS, vol. 40, no. 10, 31 October 2012 (2012-10-31)
Attorney, Agent or Firm:
HAIHONG JIACHENG INTELLECTUAL PROPERTY & PARTNERS (9th Floor, Tower B Zhongguancun Intellectual Property Mansion,No.21, South Road Haidian, Haidian District, Beijing 0, 100080, CN)
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