Title:
PRODUCTION OF AN INTACT VIRUS IN A NON-HOST CELL SYSTEM USING A SECONDARY HOST VIRAL CONSTRUCT
Document Type and Number:
WIPO Patent Application WO/2010/118188
Kind Code:
A3
Abstract:
The present invention relates to constructs and methods for the production of recombinant proteins, viruses, and viral vaccines in heterologous culture systems by expressing intact genes or viral genomes under the control of a pantropic promoter in a culture system that is not considered a host to the virus so produced. The promoter/viral genome constructs are inserted into a baculovirus and expressed in host cells that are acceptable for infection by the baculovirus.
Inventors:
DHAR ARUN K (US)
JOHNSON SYD (US)
RAINEY JONAH (US)
JOHNSON SYD (US)
RAINEY JONAH (US)
Application Number:
PCT/US2010/030314
Publication Date:
March 17, 2011
Filing Date:
April 08, 2010
Export Citation:
Assignee:
ADVANCED BIONUTRITION CORP (US)
MACROGENICS INC (US)
DHAR ARUN K (US)
JOHNSON SYD (US)
RAINEY JONAH (US)
MACROGENICS INC (US)
DHAR ARUN K (US)
JOHNSON SYD (US)
RAINEY JONAH (US)
International Classes:
C12N15/866; C12N15/33; C12N15/64
Domestic Patent References:
| WO2003048325A2 | 2003-06-12 |
Foreign References:
| US20070292952A1 | 2007-12-20 | |||
| US20040177392A1 | 2004-09-09 | |||
| US5681746A | 1997-10-28 |
Attorney, Agent or Firm:
FUIERER, Marianne et al. (PLLCP.O. Box 1370, Research Triangle Park NC, US)
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