Title:
PRODUCTION METHOD FOR AMINO-ACID POLYMER
Document Type and Number:
WIPO Patent Application WO/2018/159721
Kind Code:
A1
Abstract:
[Problem] To provide a method for producing an amino-acid polymer more easily and efficiently than conventional production methods for amino-acid polymers. [Solution] Provided is a method for producing an amino-acid polymer from thioacid amino acids. Specifically, the production method of the present invention comprises (A) a step in which first and second thioacid amino acids are prepared and (B) a step in which the first and second thioacid amino acids are oxidized to obtain a polymer of amino acids linked to each other by peptide bonding. The production method is characterized by using a thioacid amino acid containing no protective group as some of the thioacid amino acids.
Inventors:
KAJIHARA YASUHIRO (JP)
IZUMI MASAYUKI (JP)
OKAMOTO RYO (JP)
HARAGUCHI TAKUYA (JP)
MURASE TAKEFUMI (JP)
IZUMI MASAYUKI (JP)
OKAMOTO RYO (JP)
HARAGUCHI TAKUYA (JP)
MURASE TAKEFUMI (JP)
Application Number:
PCT/JP2018/007647
Publication Date:
September 07, 2018
Filing Date:
February 28, 2018
Export Citation:
Assignee:
GLYTECH INC (JP)
International Classes:
C07K1/02; C07K1/06; C07K7/00; C40B40/10
Domestic Patent References:
| WO1998056807A1 | 1998-12-17 | |||
| WO1998028434A1 | 1998-07-02 | |||
| WO1996034878A1 | 1996-11-07 |
Other References:
HARAGUCHI, TAKUYA ET AL.: "Prebiotic reaction of petide bond formation using thioacid", THE 97TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN. ANNUAL MEETING OF CSJ ; 97 (YOKOHAMA) : 2017.03.16-19, vol. 97, 3 March 2017 (2017-03-03), pages 1C3-56, XP009516073
WANG, P. ET AL.: "Promising general solution to the problem of ligating peptides and glycopeptides", J. AM. CHEM. SOC., vol. 132, no. 47, 1 December 2010 (2010-12-01), pages 17045 - 17051, XP055538400
MALI, S. M. ET AL.: "Thioacetic acid/NaSH-mediated synthesis of N-protected amino thioacids and their utility in peptide synthesis", J. ORG. CHEM., vol. 79, no. 6, 21 March 2014 (2014-03-21), pages 2377 - 2383, XP055538406
SUMIKAWA, Y. ET AL.: "Application of peptide thioacids to NCL-type sequential condensation of peptide fragments", PEPTIDE SCIENCE, vol. 2008, March 2009 (2009-03-01), pages 175 - 176, XP009516085, ISSN: 1344-7661
J. AM. CHEM. SOC., vol. 125, 2003, pages 7754 - 7755
NATURE, vol. 389, 4 September 1997 (1997-09-04)
ORG. LETT., vol. 13, no. 5, 2011
J. ORG. CHEM., vol. 79, 2014, pages 2377 - 2383
J. AM. CHEM. SOC., vol. 132, no. 47, 2010
CHEM. BER, vol. 123, 1990, pages 2081 - 2082
J. ORG. CHEM., vol. 25, 1960, pages 180 - 182
ORG. SYNTH., vol. 4, 1963, pages 924
SYNTHESIS, 2005, pages 998 - 1004
PHOSPHORUS, SULFUR, AND SILICON, vol. 178, 2003, pages 1661 - 1665
CHEM. PHARM. BULL., vol. 34, 1986, pages 999 - 1014
"CHEMICAL APPROACHES to the SYNTHESIS of PEPTIDES and PROTEIN Chapter 5 Formation of Disulfide Bridge", 1997, CRC PRESS, pages: 209 - 236
See also references of EP 3590951A4
WANG, P. ET AL.: "Promising general solution to the problem of ligating peptides and glycopeptides", J. AM. CHEM. SOC., vol. 132, no. 47, 1 December 2010 (2010-12-01), pages 17045 - 17051, XP055538400
MALI, S. M. ET AL.: "Thioacetic acid/NaSH-mediated synthesis of N-protected amino thioacids and their utility in peptide synthesis", J. ORG. CHEM., vol. 79, no. 6, 21 March 2014 (2014-03-21), pages 2377 - 2383, XP055538406
SUMIKAWA, Y. ET AL.: "Application of peptide thioacids to NCL-type sequential condensation of peptide fragments", PEPTIDE SCIENCE, vol. 2008, March 2009 (2009-03-01), pages 175 - 176, XP009516085, ISSN: 1344-7661
J. AM. CHEM. SOC., vol. 125, 2003, pages 7754 - 7755
NATURE, vol. 389, 4 September 1997 (1997-09-04)
ORG. LETT., vol. 13, no. 5, 2011
J. ORG. CHEM., vol. 79, 2014, pages 2377 - 2383
J. AM. CHEM. SOC., vol. 132, no. 47, 2010
CHEM. BER, vol. 123, 1990, pages 2081 - 2082
J. ORG. CHEM., vol. 25, 1960, pages 180 - 182
ORG. SYNTH., vol. 4, 1963, pages 924
SYNTHESIS, 2005, pages 998 - 1004
PHOSPHORUS, SULFUR, AND SILICON, vol. 178, 2003, pages 1661 - 1665
CHEM. PHARM. BULL., vol. 34, 1986, pages 999 - 1014
"CHEMICAL APPROACHES to the SYNTHESIS of PEPTIDES and PROTEIN Chapter 5 Formation of Disulfide Bridge", 1997, CRC PRESS, pages: 209 - 236
See also references of EP 3590951A4
Attorney, Agent or Firm:
NANJO, Masahiro et al. (JP)
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