Title:
PRODUCTION METHOD FOR α-AMINO NITRILE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/129538
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method of efficiently producing an α-amino nitrile compound from a non-cyclic amine compound. The production method for an α-alkylamino nitrile compound according to the present invention is characterized by subjecting a specific non-cyclic amine compound to the action of an amino acid oxidase to produce an imine compound, which is then subjected to the action of cyanide ions to obtain an α-alkylamino nitrile compound.
Inventors:
ASANO YASUHISA (JP)
YASUKAWA KAZUYUKI (JP)
YASUKAWA KAZUYUKI (JP)
Application Number:
PCT/JP2014/054017
Publication Date:
August 28, 2014
Filing Date:
February 20, 2014
Export Citation:
Assignee:
TOYAMA PREFECTURE (JP)
International Classes:
C12P13/00; C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P41/00
Foreign References:
| JP2012528834A | 2012-11-15 | |||
| JP2011501688A | 2011-01-13 | |||
| US20060051337A1 | 2006-03-09 |
Other References:
HOPWOOD J. ET AL.: "A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases.", CHEM. COMMUN., vol. 47, no. 2, 2011, pages 773 - 775, XP055212525, DOI: doi:10.1039/C0CC02919J
G.E. TRANTER: "The parity-violating energy difference between enantiomeric reactions.", CHEMICAL PHYSICS LETTERS, vol. 115, no. 3, 1985, pages 286 - 290
TORII S. ET AL.: "Apoxin I, a novel apoptosis- inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom.", J. BIOL. CHEM., vol. 272, no. 14, 1997, pages 9539 - 9542
PARK JH. ET AL.: "Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).", BIOCHEMISTRY, vol. 42, no. 42, 2003, pages 12430 - 12438
MATSUI D. ET AL.: "Mutational and crystallographic analysis of 1-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.", FEBS OPEN BIO., vol. 4, pages 220 - 228
YASUKAWA K. ET AL.: "Tailoring D-Amino Acid Oxidase from the Pig Kidney to R- Stereoselective Amine Oxidase and its Use in the Deracemization of alpha-Methylbenzylamine.", ANGEW. CHEM. INT. ED. ENGL., vol. 53, no. 17, April 2014 (2014-04-01), pages 4428 - 4431
G.E. TRANTER: "The parity-violating energy difference between enantiomeric reactions.", CHEMICAL PHYSICS LETTERS, vol. 115, no. 3, 1985, pages 286 - 290
TORII S. ET AL.: "Apoxin I, a novel apoptosis- inducing factor with L-amino acid oxidase activity purified from Western diamondback rattlesnake venom.", J. BIOL. CHEM., vol. 272, no. 14, 1997, pages 9539 - 9542
PARK JH. ET AL.: "Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).", BIOCHEMISTRY, vol. 42, no. 42, 2003, pages 12430 - 12438
MATSUI D. ET AL.: "Mutational and crystallographic analysis of 1-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813: Interconversion between oxidase and monooxygenase activities.", FEBS OPEN BIO., vol. 4, pages 220 - 228
YASUKAWA K. ET AL.: "Tailoring D-Amino Acid Oxidase from the Pig Kidney to R- Stereoselective Amine Oxidase and its Use in the Deracemization of alpha-Methylbenzylamine.", ANGEW. CHEM. INT. ED. ENGL., vol. 53, no. 17, April 2014 (2014-04-01), pages 4428 - 4431
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (JP)
Hisakazu Ueki (JP)
Hisakazu Ueki (JP)
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