Title:
PRODUCTION METHOD FOR NON-HUMAN MODEL ANIMAL WITH MENTAL DISORDER OR NEUROLOGICAL DISORDER, SAID NON-HUMAN MODEL ANIMAL, AND METHOD FOR SCREENING FOR PROPHYLACTIC OR THERAPEUTIC AGENT FOR SAID MENTAL DISORDER OR NEUROLOGICAL DISORDER
Document Type and Number:
WIPO Patent Application WO/2022/138943
Kind Code:
A1
Abstract:
Provided are: a method for producing a non-human model animal with a mental disorder or neurological disorder that is attributed to an increase or decrease in the expression of an AMPA receptor gene or an increase or decrease in the expression or function of an AMPA receptor in a predetermined region in the brain; a non-human model animal with the mental disorder or neurological disorder; and a screening method for discovering a prophylactic or therapeutic agent for the mental disorder or neurological disorder, using the non-human model animal. This method is for producing a non-human model animal with a mental disorder or neurological disorder that is attributed to an increase or decrease in the expression of an AMPA receptor gene or an increase or decrease in the expression or function of an AMPA receptor in a predetermined region in the brain. The method comprises: a step for decreasing or increasing at least one selected from the group consisting of the expression of the AMPA receptor gene or the AMPA receptor, and the function of the AMPA receptor, in the predetermined region of the non-human animal, compared to a wild type, or a step for inhibiting or activating a nervous pathway connecting the predetermined region with another region.
Inventors:
TAKAHASHI TAKUYA (JP)
MIYAZAKI TOMOYUKI (JP)
JITSUKI SUSUMU (JP)
OTA WATARU (JP)
MIYAZAKI TOMOYUKI (JP)
JITSUKI SUSUMU (JP)
OTA WATARU (JP)
Application Number:
PCT/JP2021/048329
Publication Date:
June 30, 2022
Filing Date:
December 24, 2021
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
International Classes:
A01K67/027; A61K45/00; A61P25/00; A61P25/18; A61P25/24; C12N15/09; C12N15/12
Domestic Patent References:
| WO2018131663A1 | 2018-07-19 |
Other References:
SAAB A.S., ET AL.: "Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination", SCIENCE, vol. 337, 5 July 2012 (2012-07-05), pages 749 - 753, XP055945811, DOI: 10.1126/science.1221140
NISHIOTO, YOSHINORI: "Molecular Biological Changes in ALS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 215, no. 8, 19 November 2005 (2005-11-19), JP , pages 683 - 687, XP009537796, ISSN: 0039-2359
TAKAHASHI, TAKUYA: "AMPA Receptors and Neuropsychological Disorders, Particularly Epilepsy", EPILEPSY, vol. 13, no. 2, 31 October 2019 (2019-10-31), pages 17(81) - 22(86), XP009537794, ISSN: 1882-1480
WHITE MICHAEL G., PANICKER MATTHEW, MU CHAOQI, CARTER ASHLEY M., ROBERTS BRADLEY M., DHARMASRI POORNA A., MATHUR BRIAN N.: "Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control", CELL REPORTS, ELSEVIER INC, US, vol. 22, no. 1, 1 January 2018 (2018-01-01), US , pages 84 - 95, XP055945804, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.12.023
NISHIOTO, YOSHINORI: "Molecular Biological Changes in ALS", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 215, no. 8, 19 November 2005 (2005-11-19), JP , pages 683 - 687, XP009537796, ISSN: 0039-2359
TAKAHASHI, TAKUYA: "AMPA Receptors and Neuropsychological Disorders, Particularly Epilepsy", EPILEPSY, vol. 13, no. 2, 31 October 2019 (2019-10-31), pages 17(81) - 22(86), XP009537794, ISSN: 1882-1480
WHITE MICHAEL G., PANICKER MATTHEW, MU CHAOQI, CARTER ASHLEY M., ROBERTS BRADLEY M., DHARMASRI POORNA A., MATHUR BRIAN N.: "Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control", CELL REPORTS, ELSEVIER INC, US, vol. 22, no. 1, 1 January 2018 (2018-01-01), US , pages 84 - 95, XP055945804, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.12.023
Attorney, Agent or Firm:
NIIYAMA Yuichi et al. (JP)
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