Title:
PRODUCTION METHOD FOR OXAZOLIDINONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/163731
Kind Code:
A1
Abstract:
A method for producing the compound represented by formula (3), the production method comprising steps 1 and 2 and being capable of efficiently yielding the oxazolidinone compound (3), which is an intermediate of rivaroxaban, which is useful as a medicine.
Step 1: a step in which the compound represented by formula (1) is reacted with the compound represented by formula (2) in acetonitrile in the presence of a trifluoromethanesulfonate. Step 2: a step in which the mixture obtained in step 1 is reacted with 1,1'-carbonyldiimidazole to obtain the compound represented by formula (3). The present invention further provides: a method for producing a hydrochloride of the compound represented by formula (4) from the obtained compound represented by formula (3); and a method for producing the compound represented by formula (6) from the hydrochloride of the compound represented by formula (4).
Inventors:
AKIYAMA TOSHIHIKO (JP)
OKURA YUKA (JP)
OKURA YUKA (JP)
Application Number:
PCT/JP2019/005969
Publication Date:
August 29, 2019
Filing Date:
February 19, 2019
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07D413/14; C07D413/10
Domestic Patent References:
| WO2014155259A2 | 2014-10-02 |
Foreign References:
| JP2007517816A | 2007-07-05 | |||
| US20150038704A1 | 2015-02-05 | |||
| CN104031036A | 2014-09-10 | |||
| JP2010530385A | 2010-09-09 | |||
| JP2005524660A | 2005-08-18 |
Other References:
FATTAH, TANZEELA A. ET AL.: "A review on the synthetic approaches of rivaroxaban: An anticoagulant drug", TETRAHEDRON : ASYMMETRY, vol. 28, no. 4, 2017, pages 485 - 504, XP085010267, doi:10.1016/j.tetasy.2017.02.010
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (JP)
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