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Patent Searching and Data


Title:
PRODUCTION METHOD FOR PANCREAS-DERIVED SOMATIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2014/038652
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method and the like for efficiently growing pancreas-derived somatic stem cells. This production method for pancreas-derived somatic stem cells comprises the following steps (A) and (B): a step (A) in which a group of cells including cells that constitute the pancreas are made to pass through the G0 phase or the G1 phase, and a gene for a protein that is active in causing a transition to the S phase is expressed; and a step (B) in which the cells obtained at the (A) step are cultivated in the presence of an extracellular growth factor.

Inventors:
HIJIKATA MAKOTO (JP)
YAMAGUCHI TATSUYA (JP)
Application Number:
PCT/JP2013/074026
Publication Date:
March 13, 2014
Filing Date:
September 06, 2013
Export Citation:
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Assignee:
UNIV KYOTO (JP)
TOYO BOSEKI (JP)
International Classes:
C12N5/071; A61K35/39; A61L27/00; A61P5/48; A61P43/00; C12N5/10; C12N15/09
Foreign References:
EP2380972A12011-10-26
Other References:
CHEN S. ET AL.: "Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration", CELL CYCLE, vol. 11, no. 4, 15 February 2012 (2012-02-15), pages 695 - 705
ZHANG Y.Q. ET AL.: "Identification and expansion of pancreatic stem/progenitor cells", J. CELL. MOL. MED., vol. 9, no. 2, June 2005 (2005-06-01), pages 331 - 344
ARTEGIANI B. ET AL.: "Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain", J. EXP. MED., vol. 208, no. 5, 9 May 2011 (2011-05-09), pages 937 - 948
LANGE C. ET AL.: "Cdk4/cyclinDl overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors", CELL STEM CELL, vol. 5, no. 3, 4 September 2009 (2009-09-04), pages 320 - 331
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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