Title:
PRODUCTION METHOD FOR PENTOSAN POLYSULFATE
Document Type and Number:
WIPO Patent Application WO/2018/043668
Kind Code:
A1
Abstract:
The present invention provides a production method for pentosan polysulfate. The production method includes: a first step for obtaining an acidic xylooligosaccharide from a plant-derived starting material; and a second step for obtaining pentosan polysulfate from the acidic xylooligosaccharide. The first step includes a depolymerization step for the plant-derived starting material, and the second step includes a sulfating step for the acidic xylooligosaccharide. The depolymerization step is followed by a deacetylation step for adding a base to achieve a pH of at least 11. The production method makes it possible to obtain pentosan polysulfate that has a low acetyl group content. The production method also makes it possible to cheaply and efficiently obtain high yields of pentosan polysulfate.
Inventors:
ISHIKAWA KOTARO (JP)
KASHIWAMURA TAKURO (JP)
KATO TAKUYA (JP)
KOGA TORU (JP)
ISHIKAWA SUGURU (JP)
KASHIWAMURA TAKURO (JP)
KATO TAKUYA (JP)
KOGA TORU (JP)
ISHIKAWA SUGURU (JP)
Application Number:
PCT/JP2017/031434
Publication Date:
March 08, 2018
Filing Date:
August 31, 2017
Export Citation:
Assignee:
OJI HOLDINGS CORP (JP)
International Classes:
C08B37/00
Domestic Patent References:
| WO2014114723A1 | 2014-07-31 | |||
| WO2005117912A1 | 2005-12-15 | |||
| WO2007138263A1 | 2007-12-06 | |||
| WO2016184887A1 | 2016-11-24 | |||
| WO2010000013A1 | 2010-01-07 | |||
| WO2014114723A1 | 2014-07-31 |
Foreign References:
| JPS4843100A | 1973-06-22 | |||
| JP2003183303A | 2003-07-03 |
Other References:
MITSURO ISHIHARA ET AL.: "Isolation of Xylan from Hardwood by Alkali Extraction and Steam Treatment", JOURNAL OF WOOD SCIENCE, vol. 42, no. 12, 1996, pages 1211 - 1220, XP055581018, ISSN: 0021-4795
KABEL, M. A. ET AL.: "Hydrothermally treated xylan rich by-products yield different classes of xylo-oligosaccharides", CARBOHYDRATE POLYMERS, vol. 50, no. 1, 2002, pages 47 - 56, XP004357942, DOI: doi:10.1016/S0144-8617(02)00045-0
KABEL, M. A. ET AL.: "Complex xylo- oligosaccharides identified from hydrothermally treated Eucalyptus wood and brewery's spent grain", CARBOHYDRATE POLYMERS, vol. 50, no. 2, 2002, pages 191 - 200, XP004367044, DOI: doi:10.1016/S0144-8617(02)00022-X
KOUTANIEMI, S. ET AL.: "Distinct roles of carbohydrate esterase family CE16 acetyl esterases and polymer-acting acetyl xylan esterases in xylan deacetylation", JOURNAL OF BIOTECHNOLOGY, vol. 168, no. 4, 2013, pages 684 - 92, XP028789075, DOI: doi:10.1016/j.jbiotec.2013.10.009
PAWAR, P. M. A. ET AL.: "Acetylation of woody lignocellulose: significance and regulation", FRONTIERS IN PLANT SCIENCE, vol. 4, no. 118, 2013, pages 1 - 8, XP055471705, DOI: 10.3389/fpls.2013.00118
"Wood Chemicals no Gijyutsu (Techniques of Wood Chemicals", 2007, CMC PUBLISHING CO., LTD., pages: 108
KABEL, M. A. ET AL.: "Hydrothermally treated xylan rich by-products yield different classes of xylo-oligosaccharides", CARBOHYDRATE POLYMERS, vol. 50, no. 1, 2002, pages 47 - 56, XP004357942, DOI: doi:10.1016/S0144-8617(02)00045-0
KABEL, M. A. ET AL.: "Complex xylo- oligosaccharides identified from hydrothermally treated Eucalyptus wood and brewery's spent grain", CARBOHYDRATE POLYMERS, vol. 50, no. 2, 2002, pages 191 - 200, XP004367044, DOI: doi:10.1016/S0144-8617(02)00022-X
KOUTANIEMI, S. ET AL.: "Distinct roles of carbohydrate esterase family CE16 acetyl esterases and polymer-acting acetyl xylan esterases in xylan deacetylation", JOURNAL OF BIOTECHNOLOGY, vol. 168, no. 4, 2013, pages 684 - 92, XP028789075, DOI: doi:10.1016/j.jbiotec.2013.10.009
PAWAR, P. M. A. ET AL.: "Acetylation of woody lignocellulose: significance and regulation", FRONTIERS IN PLANT SCIENCE, vol. 4, no. 118, 2013, pages 1 - 8, XP055471705, DOI: 10.3389/fpls.2013.00118
"Wood Chemicals no Gijyutsu (Techniques of Wood Chemicals", 2007, CMC PUBLISHING CO., LTD., pages: 108
Attorney, Agent or Firm:
SIKS & CO. (JP)
Download PDF: