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Patent Searching and Data


Title:
PRODUCTION METHOD FOR RAMELTEON
Document Type and Number:
WIPO Patent Application WO/2018/207888
Kind Code:
A1
Abstract:
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene]acetaldehyde, which is an easily available enal, is asymmetrically reduced to produce (S)-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetaldehyde, which is an optically active aldehyde.

Inventors:
NISHIYAMA, Akira (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
ITO, Noriyuki (1-8 Takasagocho Miyamaecho, Takasago-sh, Hyogo 88, 〒6768688, JP)
Application Number:
JP2018/018199
Publication Date:
November 15, 2018
Filing Date:
May 10, 2018
Export Citation:
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Assignee:
KANEKA CORPORATION (2-3-18, Nakanoshima Kita-ku, Osaka-sh, Osaka 88, 〒5308288, JP)
International Classes:
C07D307/80; C07D307/81; C12P17/04; A61K31/343; A61P25/20; C07B53/00; C07B61/00
Domestic Patent References:
WO2011108672A22011-09-09
Foreign References:
JPH1180106A1999-03-26
CN104109143A2014-10-22
US20110294171A12011-12-01
JP2007185133A2007-07-26
JP2009526531A2009-07-23
Other References:
DATABASE CAS [o] 6 December 2015 (2015-12-06), retrieved from SIN Database accession no. 1823787-31-0
Attorney, Agent or Firm:
UEKI, Kyuichi et al. (Fujita-Toyobo Building 9th floor, 1-16 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, 〒5300003, JP)
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