Title:
PRODUCTION METHOD FOR SHEET-LIKE RETINAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2023/090427
Kind Code:
A1
Abstract:
A production method for a cell aggregate containing a retinal tissue having a layer structure, the method comprising performing suspension culturing or adhesive culturing of a dispersed retinal cell population in a medium containing a Wnt signal transduction pathway acting substance, wherein the retinal cell population includes at least one type of cells selected from the group consisting of retinal precursor cells and photoreceptor precursor cells.
Inventors:
MANDAI MICHIKO (JP)
TAKAHASHI MASAYO (JP)
YAMASAKI SUGURU (JP)
HORIUCHI MATSURI (JP)
TAKAHASHI MASAYO (JP)
YAMASAKI SUGURU (JP)
HORIUCHI MATSURI (JP)
Application Number:
PCT/JP2022/042876
Publication Date:
May 25, 2023
Filing Date:
November 18, 2022
Export Citation:
Assignee:
RIKEN (JP)
SUMITOMO PHARMA CO LTD (JP)
SUMITOMO CHEMICAL CO (JP)
SUMITOMO PHARMA CO LTD (JP)
SUMITOMO CHEMICAL CO (JP)
International Classes:
C12N5/071; A61K35/30; A61L27/36; A61L27/38; A61L27/52; A61L27/58; A61P27/02; C07K14/78; C12M3/00; C12N5/074
Domestic Patent References:
| WO2022054925A1 | 2022-03-17 |
Foreign References:
| JP2020522522A | 2020-07-30 |
Other References:
NAKAGAWA, SHINICHI: "Induction of stratification and stem cell maintenance activity under culture conditions by Wnt signaling", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 4, no. 2, 1 May 2005 (2005-05-01), JP , pages 89 - 94, XP009546348, ISSN: 1347-7919
JIN CAIXIA, OU QINGJIAN, LI ZONGYI, WANG JUAN, ZHANG JIEPING, TIAN HAIBIN, XU JING-YING, GAO FURONG, LU LIXIA, XU GUO-TONG: "The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells", STEM CELL RESEARCH & THERAPY, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 346, XP093066529, DOI: 10.1186/s13287-018-1091-y
JIN CAIXIA, OU QINGJIAN, LI ZONGYI, WANG JUAN, ZHANG JIEPING, TIAN HAIBIN, XU JING-YING, GAO FURONG, LU LIXIA, XU GUO-TONG: "The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells", STEM CELL RESEARCH & THERAPY, vol. 9, no. 1, 1 December 2018 (2018-12-01), pages 346, XP093066529, DOI: 10.1186/s13287-018-1091-y
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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