Title:
PRODUCTION OF MONATIN AND MONATIN PRECURSORS
Document Type and Number:
WIPO Patent Application WO2005042756
Kind Code:
A3
Abstract:
Methods and compositions that can be used to make monatin or salt thereof from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
Inventors:
MCFARLAN SARA C (US)
HICKS PAULA M (US)
ZIDWICK MARY JO (US)
SANCHEZ-RIERA FERNANDO A (US)
CAMERON DOUGLAS C (US)
DESOUZA MERVYN L (US)
ROSAZZA JACK (US)
GORT STEVEN J (US)
HICKS PAULA M (US)
ZIDWICK MARY JO (US)
SANCHEZ-RIERA FERNANDO A (US)
CAMERON DOUGLAS C (US)
DESOUZA MERVYN L (US)
ROSAZZA JACK (US)
GORT STEVEN J (US)
Application Number:
PCT/US2004/034558
Publication Date:
November 24, 2005
Filing Date:
October 21, 2004
Export Citation:
Assignee:
CARGILL INC (US)
MCFARLAN SARA C (US)
HICKS PAULA M (US)
ZIDWICK MARY JO (US)
SANCHEZ-RIERA FERNANDO A (US)
CAMERON DOUGLAS C (US)
DESOUZA MERVYN L (US)
ROSAZZA JACK (US)
GORT STEVEN J (US)
MCFARLAN SARA C (US)
HICKS PAULA M (US)
ZIDWICK MARY JO (US)
SANCHEZ-RIERA FERNANDO A (US)
CAMERON DOUGLAS C (US)
DESOUZA MERVYN L (US)
ROSAZZA JACK (US)
GORT STEVEN J (US)
International Classes:
C12N1/21; C12N9/02; C12N9/10; C12N9/88; C12P13/04; C12P17/10; (IPC1-7): C12P13/04; C12N9/88; C12N9/10; C12N1/21
Domestic Patent References:
| WO2003056026A1 | 2003-07-10 |
Foreign References:
| US3002889A | 1961-10-03 | |||
| US3399114A | 1968-08-27 | |||
| US5994559A | 1999-11-30 |
Other References:
ATCC: "Bacteria", INTERNET ARTICLE, XP002321015, Retrieved from the Internet [retrieved on 20050311]
NAKAMURA K ET AL: "TOTAL SYNTHESIS OF MONATIN", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 19, 2000, pages 2967 - 2970, XP002964364, ISSN: 1523-7060
OLIVEIRA D D J ET AL: "Diastereoselective formation of a quaternary center in a pyroglutamate derivative. Formal synthesis of Monatin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 39, 24 September 2001 (2001-09-24), pages 6793 - 6796, XP004317777, ISSN: 0040-4039
NAKAMURA K ET AL: "TOTAL SYNTHESIS OF MONATIN", ORGANIC LETTERS, ACS, WASHINGTON, DC, US, vol. 2, no. 19, 2000, pages 2967 - 2970, XP002964364, ISSN: 1523-7060
OLIVEIRA D D J ET AL: "Diastereoselective formation of a quaternary center in a pyroglutamate derivative. Formal synthesis of Monatin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 42, no. 39, 24 September 2001 (2001-09-24), pages 6793 - 6796, XP004317777, ISSN: 0040-4039
Download PDF:
Previous Patent: MICROBIOLOGICAL METHOD FOR THE PREPARATION OF MENADIONE
Next Patent: EXPRESSION PROFILING USING MICROARRAYS
Next Patent: EXPRESSION PROFILING USING MICROARRAYS