Title:
PRODUCTION OF PROBIOTICS BY IN VITRO ENRICHMENT OF BENEFICIAL MICROORGANISMS FROM HUMAN OR ANIMAL MICROBIOTA
Document Type and Number:
WIPO Patent Application WO/2015/026235
Kind Code:
A3
Abstract:
The present invention is directed to a method of treating a dysbiosis in a mammal, preferably a human, by taking a sample of the micro-organisms that are causative of the dysbiosis, whereafter said sample is enriched in vitro for healthy bacteria, after which the sample is replaced.
Inventors:
KORT REMCO (NL)
SCHUREN FRANK HENRI JOHAN (NL)
SCHUREN FRANK HENRI JOHAN (NL)
Application Number:
PCT/NL2014/050570
Publication Date:
August 27, 2015
Filing Date:
August 22, 2014
Export Citation:
Assignee:
TNO (NL)
International Classes:
A61K35/741; A61K35/74; A61P43/00
Foreign References:
| US20030118571A1 | 2003-06-26 |
Other References:
FALAGAS M E ET AL: "Probiotics for the treatment of women with bacterial vaginosis", CLINICAL MICROBIOLOGY AND INFECTION, WILEY-BLACKWELL PUBLISHING LTD, UNITED KINGDOM, SWITZERLAND, vol. 13, no. 7, 1 July 2007 (2007-07-01), pages 657 - 664, XP002631583, ISSN: 1198-743X, [retrieved on 20070302], DOI: 10.1111/J.1469-0691.2007.01688.X
TEITELBAUM JONATHAN E ET AL: "Nutritional impact of pre- and probiotics as protective gastrointestinal organisms", ANNUAL REVIEW OF NUTRITION, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 22, 1 January 2002 (2002-01-01), pages 107 - 138, XP009107660, ISSN: 0199-9885, DOI: 10.1146/ANNUREV.NUTR.22.110901.145412
WHITEMAN, H. (2013, AUGUST 8).: ""Fewer 'good gut' bacteria in C-section infants", 8 August 2013 (2013-08-08), pages 1 - 2, XP002735472, Retrieved from the Internet [retrieved on 20141202]
J. RAVEL ET AL: "Vaginal microbiome of reproductive-age women", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. Supplement_1, 15 March 2011 (2011-03-15), pages 4680 - 4687, XP055083668, ISSN: 0027-8424, DOI: 10.1073/pnas.1002611107
A. EVERARD ET AL: "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 22, 28 May 2013 (2013-05-28), pages 9066 - 9071, XP055074467, ISSN: 0027-8424, DOI: 10.1073/pnas.1219451110
P. B. ECKBURG: "Diversity of the Human Intestinal Microbial Flora", SCIENCE, vol. 308, no. 5728, 10 June 2005 (2005-06-10), pages 1635 - 1638, XP055050950, ISSN: 0036-8075, DOI: 10.1126/science.1110591
STRATIKI ET AL: "The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants", EARLY HUMAN DEVELOPMENT, SHANNON, IR, vol. 83, no. 9, 14 September 2007 (2007-09-14), pages 575 - 579, XP022245155, ISSN: 0378-3782, DOI: 10.1016/J.EARLHUMDEV.2006.12.002
SAAVEDRA J M: "Use of probiotics in pediatrics: Rationale, mechanisms of action, and practical aspects", NUTRITION IN CLINICAL PRACTICE, WILLIAMS AND WLIKINS, BALTIMORE, MD, US, vol. 22, no. 3, 1 June 2007 (2007-06-01), pages 351 - 365, XP009129949, ISSN: 0884-5336, DOI: 10.1177/0115426507022003351
HEDVIG E JAKOBSSON ET AL: "Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section", GUT, vol. 63, no. 4, 7 August 2013 (2013-08-07), pages 559 - 566, XP009181476, ISSN: 0017-5749, [retrieved on 20130807]
TEITELBAUM JONATHAN E ET AL: "Nutritional impact of pre- and probiotics as protective gastrointestinal organisms", ANNUAL REVIEW OF NUTRITION, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 22, 1 January 2002 (2002-01-01), pages 107 - 138, XP009107660, ISSN: 0199-9885, DOI: 10.1146/ANNUREV.NUTR.22.110901.145412
WHITEMAN, H. (2013, AUGUST 8).: ""Fewer 'good gut' bacteria in C-section infants", 8 August 2013 (2013-08-08), pages 1 - 2, XP002735472, Retrieved from the Internet
J. RAVEL ET AL: "Vaginal microbiome of reproductive-age women", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 108, no. Supplement_1, 15 March 2011 (2011-03-15), pages 4680 - 4687, XP055083668, ISSN: 0027-8424, DOI: 10.1073/pnas.1002611107
A. EVERARD ET AL: "Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 22, 28 May 2013 (2013-05-28), pages 9066 - 9071, XP055074467, ISSN: 0027-8424, DOI: 10.1073/pnas.1219451110
P. B. ECKBURG: "Diversity of the Human Intestinal Microbial Flora", SCIENCE, vol. 308, no. 5728, 10 June 2005 (2005-06-10), pages 1635 - 1638, XP055050950, ISSN: 0036-8075, DOI: 10.1126/science.1110591
STRATIKI ET AL: "The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants", EARLY HUMAN DEVELOPMENT, SHANNON, IR, vol. 83, no. 9, 14 September 2007 (2007-09-14), pages 575 - 579, XP022245155, ISSN: 0378-3782, DOI: 10.1016/J.EARLHUMDEV.2006.12.002
SAAVEDRA J M: "Use of probiotics in pediatrics: Rationale, mechanisms of action, and practical aspects", NUTRITION IN CLINICAL PRACTICE, WILLIAMS AND WLIKINS, BALTIMORE, MD, US, vol. 22, no. 3, 1 June 2007 (2007-06-01), pages 351 - 365, XP009129949, ISSN: 0884-5336, DOI: 10.1177/0115426507022003351
HEDVIG E JAKOBSSON ET AL: "Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section", GUT, vol. 63, no. 4, 7 August 2013 (2013-08-07), pages 559 - 566, XP009181476, ISSN: 0017-5749, [retrieved on 20130807]
Attorney, Agent or Firm:
JANSEN, C.m. (Johan de Wittlaan 7, JR Den Haag, NL)
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