Title:
PRODUCTION OF RECOMBINANT PRODUCTS USING CAPILLARY MEMBRANES
Document Type and Number:
WIPO Patent Application WO2007004172
Kind Code:
A8
Abstract:
The invention provides for a method of producing at least one recombinant product under aerated conditions. The method includes providing a porous substrate having a first side and a second side and which has a biofilm of microorganisms attached to the first side thereof, the substrate being configured to allow passage of a nutrient solution therethrough and to prevent the passage of microorganism cells therethrough. The method further includes causing a nutrient solution to flow through the substrate and the biofilm in a direction from the second side thereof to the first side thereof under aerated conditions, at a rate which is sufficiently low for a nutrient gradient having a concentration differential to be established across the biofilm, and the microorganisms being induced to produce recombinant product.
Inventors:
LEUKES WINSTON DANIEL (ZA)
FRASER SHEENA JANET (ZA)
FRASER SHEENA JANET (ZA)
Application Number:
PCT/IB2006/052204
Publication Date:
April 12, 2007
Filing Date:
June 30, 2006
Export Citation:
Assignee:
SYNEXA LIFE SCIENCES PROPRIETA (ZA)
LEUKES WINSTON DANIEL (ZA)
FRASER SHEENA JANET (ZA)
LEUKES WINSTON DANIEL (ZA)
FRASER SHEENA JANET (ZA)
International Classes:
C12N15/09
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