Title:
PRODUCTION OF SALTS OF 4-HYDROXYBUTYRATE USING BIOBASED RAW MATERIALS
Document Type and Number:
WIPO Patent Application WO/2014/078014
Kind Code:
A3
Abstract:
Gamma-butyrolactone ("GBL") and Gamma-hydroxybutyrate ("GHB") having a unique carbon footprint as defined by the percent modern carbon (pmc) are described herein. The percent modern carbon can be controlled by varying the amounts of biobased, renewable starting materials and petroleum-based starting materials to prepare GBL or GHB having a defined pmc or by preparing mixtures of GBL or GHB prepared from biobased renewable starting materials and GBL or GHB prepared from petroleum-based starting materials.
More Like This:
Inventors:
PEOPLES OLIVER (US)
SAMUELSON DEREK (US)
SENECHAL MAX (US)
PARK SUNG MIN (US)
GREDDER JOSEPH (US)
MIRLEY CHRISTOPHER (US)
SAMUELSON DEREK (US)
SENECHAL MAX (US)
PARK SUNG MIN (US)
GREDDER JOSEPH (US)
MIRLEY CHRISTOPHER (US)
Application Number:
PCT/US2013/065916
Publication Date:
July 17, 2014
Filing Date:
October 21, 2013
Export Citation:
Assignee:
METABOLIX INC (US)
International Classes:
C07D307/06; C07C59/01; C07D307/33
Domestic Patent References:
| WO2010124046A1 | 2010-10-28 | |||
| WO2001019361A2 | 2001-03-22 | |||
| WO2009059253A2 | 2009-05-07 | |||
| WO2010053691A1 | 2010-05-14 | |||
| WO2011100601A1 | 2011-08-18 |
Foreign References:
| US20060210630A1 | 2006-09-21 |
Other References:
C. SAUDAN ET AL: "Detection of Exogenous GHB in Blood by Gas Chromatography-Combustion-Isotope Ratio Mass Spectrometry: Implications in Postmortem Toxicology", JOURNAL OF ANALYTICAL TOXICOLOGY, vol. 29, no. 8, 1 November 2005 (2005-11-01), pages 777 - 781, XP055097487, ISSN: 0146-4760, DOI: 10.1093/jat/29.8.777
FRANÇOIS MARCLAY ET AL: "Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 400, no. 4, 1 May 2011 (2011-05-01), pages 1105 - 1112, XP055097350, ISSN: 1618-2642, DOI: 10.1007/s00216-011-4891-9
MARCLAY F ET AL: "Potential of IRMS technology for tracing gamma-butyrolactone (GBL)", FORENSIC SCIENCE INTERNATIONAL, ELSEVIER SCIENTIFIC PUBLISHERS IRELAND LTD, IE, vol. 198, no. 1-3, 20 May 2010 (2010-05-20), pages 46 - 52, XP027020697, ISSN: 0379-0738, [retrieved on 20100106]
STRUYS ET AL: "Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase", METABOLISM, CLINICAL AND EXPERIMENTAL, W.B. SAUNDERS CO., PHILADELPHIA, PA, US, vol. 55, no. 3, 1 March 2006 (2006-03-01), pages 353 - 358, XP005285599, ISSN: 0026-0495, DOI: 10.1016/J.METABOL.2005.09.009
"UNDERSTANDING BIOBASED CARBON CONTENT Society of the Plastics Industry Bioplastics Council", 28 February 2012 (2012-02-28), XP055097769, Retrieved from the Internet [retrieved on 20140122]
DATABASE PUBCHEM [online] NCBI; 17 September 2005 (2005-09-17), XP002719249, Database accession no. CID4737262
FRANÇOIS MARCLAY ET AL: "Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 400, no. 4, 1 May 2011 (2011-05-01), pages 1105 - 1112, XP055097350, ISSN: 1618-2642, DOI: 10.1007/s00216-011-4891-9
MARCLAY F ET AL: "Potential of IRMS technology for tracing gamma-butyrolactone (GBL)", FORENSIC SCIENCE INTERNATIONAL, ELSEVIER SCIENTIFIC PUBLISHERS IRELAND LTD, IE, vol. 198, no. 1-3, 20 May 2010 (2010-05-20), pages 46 - 52, XP027020697, ISSN: 0379-0738, [retrieved on 20100106]
STRUYS ET AL: "Metabolism of gamma-hydroxybutyrate to d-2-hydroxyglutarate in mammals: further evidence for d-2-hydroxyglutarate transhydrogenase", METABOLISM, CLINICAL AND EXPERIMENTAL, W.B. SAUNDERS CO., PHILADELPHIA, PA, US, vol. 55, no. 3, 1 March 2006 (2006-03-01), pages 353 - 358, XP005285599, ISSN: 0026-0495, DOI: 10.1016/J.METABOL.2005.09.009
"UNDERSTANDING BIOBASED CARBON CONTENT Society of the Plastics Industry Bioplastics Council", 28 February 2012 (2012-02-28), XP055097769, Retrieved from the Internet
DATABASE PUBCHEM [online] NCBI; 17 September 2005 (2005-09-17), XP002719249, Database accession no. CID4737262
Attorney, Agent or Firm:
TERAPANE, Michael J. et al. (1545 Peachtree Street N.E.,Suite 32, Atlanta GA, US)
Download PDF: