Title:
PRODUCTION OF TACROLIMUS (FK-506) USING NEW STREPTOMYCES SPECIES
Document Type and Number:
WIPO Patent Application WO2005038009
Kind Code:
A3
Abstract:
The invention relates to a new microorganism Streptomyces glaucescens MTCC 5115 and a process for producing the immunosuppressant agent, tacrolimus (FK-506) utilizing the new microorganism Streptomyces glaucescens MTCC 5115. The invention also relates to pharmaceutical compositions that include the tacrolimus (FK-506) and use of said compositions for treatment or prevention of the transplantation rejection of organs or tissues such as heart, kidney, liver, medulla ossium, skin, etc.
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Inventors:
KUMAR PARVEEN (IN)
SHARMA SUNITA (IN)
SHUKLA ANIRUDDHA (IN)
KUMAR SUDEEP (IN)
MAURYA RAJ KUMAR (IN)
KATIAL VIKAS (IN)
MITRA ASHOKE (IN)
GIGRAS PARESH (IN)
SHARMA SUNITA (IN)
SHUKLA ANIRUDDHA (IN)
KUMAR SUDEEP (IN)
MAURYA RAJ KUMAR (IN)
KATIAL VIKAS (IN)
MITRA ASHOKE (IN)
GIGRAS PARESH (IN)
Application Number:
PCT/IB2004/003380
Publication Date:
June 16, 2005
Filing Date:
October 15, 2004
Export Citation:
Assignee:
RANBAXY LAB LTD (IN)
KUMAR PARVEEN (IN)
SHARMA SUNITA (IN)
SHUKLA ANIRUDDHA (IN)
KUMAR SUDEEP (IN)
MAURYA RAJ KUMAR (IN)
KATIAL VIKAS (IN)
MITRA ASHOKE (IN)
GIGRAS PARESH (IN)
KUMAR PARVEEN (IN)
SHARMA SUNITA (IN)
SHUKLA ANIRUDDHA (IN)
KUMAR SUDEEP (IN)
MAURYA RAJ KUMAR (IN)
KATIAL VIKAS (IN)
MITRA ASHOKE (IN)
GIGRAS PARESH (IN)
International Classes:
A61K31/535; C12N1/20; C12P17/18; (IPC1-7): C12N1/20; C12P17/18; A61K31/535; C12R1/465
Foreign References:
US5194378A | 1993-03-16 | |||
US5116756A | 1992-05-26 | |||
US4894366A | 1990-01-16 | |||
US5624842A | 1997-04-29 |
Other References:
MOTAMEDI H ET AL: "The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 256, no. 3, 1998, pages 528 - 534, XP000906738, ISSN: 0014-2956
REYNOLDS K A ET AL: "Rapamycin, FK506, and ascomycin-related compounds", DRUGS AND THE PHARMACEUTICAL SCIENCES, vol. 82, no. 82, 1997, pages 497 - 520, XP000906777, ISSN: 0360-2583
REYNOLDS K A ET AL: "Rapamycin, FK506, and ascomycin-related compounds", DRUGS AND THE PHARMACEUTICAL SCIENCES, vol. 82, no. 82, 1997, pages 497 - 520, XP000906777, ISSN: 0360-2583
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