Title:
PROFILING FRAGMENTS OF ELASTIC FIBERS AND MICROFIBRILS AS BIOMARKERS FOR DISEASE
Document Type and Number:
WIPO Patent Application WO/2010/129270
Kind Code:
A3
Abstract:
The present invention makes use of immunoassays, such as sandwich ELISAs, to profile the circulating concentration of elastic fiber and microfibril fragments in samples from individuals with diseases associated with elastic fiber and/or microfibril degradation. Examples of such diseases include, Marfan' s syndrome, aortic aneurysm, and scleroderma. Profiling the concentration of such fragments can be used to diagnose disease and monitor disease progression.
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Inventors:
SAKAI LYNN Y (US)
MARSHALL LYNN (US)
CARLSON ERIC J (US)
CHARBONNEAU NOE L (US)
HAYFLICK SUSAN J (US)
MARSHALL LYNN (US)
CARLSON ERIC J (US)
CHARBONNEAU NOE L (US)
HAYFLICK SUSAN J (US)
Application Number:
PCT/US2010/032551
Publication Date:
April 21, 2011
Filing Date:
April 27, 2010
Export Citation:
Assignee:
SHRINERS HOSPITALS CHILDREN (US)
UNIV OREGON HEALTH & SCIENCE (US)
SAKAI LYNN Y (US)
MARSHALL LYNN (US)
CARLSON ERIC J (US)
CHARBONNEAU NOE L (US)
HAYFLICK SUSAN J (US)
UNIV OREGON HEALTH & SCIENCE (US)
SAKAI LYNN Y (US)
MARSHALL LYNN (US)
CARLSON ERIC J (US)
CHARBONNEAU NOE L (US)
HAYFLICK SUSAN J (US)
International Classes:
G01N33/53; A01K67/027; C07K16/18; G01N33/577
Foreign References:
| US20070224643A1 | 2007-09-27 | |||
| US20050282163A1 | 2005-12-22 | |||
| US20040126788A1 | 2004-07-01 | |||
| US20060094054A1 | 2006-05-04 | |||
| US20040157246A1 | 2004-08-12 | |||
| US20080090759A1 | 2008-04-17 | |||
| US6048704A | 2000-04-11 |
Other References:
CHIU-LIANG KUO ET AL.: "Effects of Fibrillin-1 Degradation on Microfibril Ultrastructure.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 6, 2007, pages 4007 - 4020
Attorney, Agent or Firm:
HULSEBERG, Daniel, J. et al. (30 Rockefeller PlazaNew York, NY, US)
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