Title:
PROGESTERON RECEPTOR MODULATORS FOR USE IN THE THERAPY OF UTERINE FIBROIDS
Document Type and Number:
WIPO Patent Application WO/2014/167510
Kind Code:
A3
Abstract:
The present invention relates to a long-term therapy including repeated treatment courses of ulipristal acetate or any metabolite thereof for treating uterine fibroids. The present invention also relates to a combined therapy applying ulipristal acetate with a progestin in order to improve the currently used treatment for uterine fibroids.
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Inventors:
BESTEL ELKE (FR)
OSTERLOH IAN (GB)
LOUMAYE ERNEST (CH)
DACQUIN ANNIE (FR)
JEAN FLORENCE (FR)
OSTERLOH IAN (GB)
LOUMAYE ERNEST (CH)
DACQUIN ANNIE (FR)
JEAN FLORENCE (FR)
Application Number:
PCT/IB2014/060558
Publication Date:
February 19, 2015
Filing Date:
April 09, 2014
Export Citation:
Assignee:
PREGLEM SA (CH)
International Classes:
A61K31/57; A61P15/00
Domestic Patent References:
| WO2005097193A2 | 2005-10-20 |
Foreign References:
| US20050215536A1 | 2005-09-29 |
Other References:
MELIS G B ET AL: "Pharmacokinetic evaluation of ulipristal acetate for uterine leiomyoma treatment", EXPERT OPINION ON DRUG METABOLISM AND TOXICOLOGY 2012 INFORMA HEALTHCARE GBR, vol. 8, no. 7, July 2012 (2012-07-01), pages 901 - 908, XP009179108, ISSN: 1742-5255
LYNNETTE K. NIEMAN ET AL: "Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study", FERTILITY AND STERILITY, vol. 95, no. 2, 1 February 2011 (2011-02-01), pages 767 - 772.e2, XP055129509, ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2010.09.059
DONNEZ J ET AL: "Ulipristal acetate versus placebo for fibroid treatment before surgery", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 366, no. 5, 2 February 2012 (2012-02-02), pages 409 - 420, XP002676689, ISSN: 1533-4406
JACQUES DONNEZ ET AL: "Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids", NEW ENGLAND JOURNAL OF MEDICINE, vol. 366, no. 5, 2 February 2012 (2012-02-02), pages 421 - 432, XP055129514, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1103180
LYNNETTE K. NIEMAN ET AL: "Efficacy and tolerability of CDB-2914 treatment for symptomatic uterine fibroids: a randomized, double-blind, placebo-controlled, phase IIb study", FERTILITY AND STERILITY, vol. 95, no. 2, 1 February 2011 (2011-02-01), pages 767 - 772.e2, XP055129509, ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2010.09.059
DONNEZ J ET AL: "Ulipristal acetate versus placebo for fibroid treatment before surgery", NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, vol. 366, no. 5, 2 February 2012 (2012-02-02), pages 409 - 420, XP002676689, ISSN: 1533-4406
JACQUES DONNEZ ET AL: "Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids", NEW ENGLAND JOURNAL OF MEDICINE, vol. 366, no. 5, 2 February 2012 (2012-02-02), pages 421 - 432, XP055129514, ISSN: 0028-4793, DOI: 10.1056/NEJMoa1103180
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