Title:
PROGESTOGEN-ANTIPROGESTOGEN REGIMENS
Document Type and Number:
WIPO Patent Application WO1999025360
Kind Code:
A3
Abstract:
An estrogen-free contraceptive is provided which does not have the bleeding-related drawbacks of conventional progestogen-only pills. Thus the invention is a contraceptive kit comprising a combined means for the simultaneous daily administration of a progestogen as the sole contraceptively effective ingredient and an anti-progestogen. Said combined means preferably is in the form of tablets having a normal contraceptive dose of the progestogen and low dose of the anti-progestogen.
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Inventors:
COELINGH BENNINK HERMAN JAN TI (NL)
Application Number:
PCT/EP1998/007221
Publication Date:
July 29, 1999
Filing Date:
November 10, 1998
Export Citation:
Assignee:
AKZO NOBEL NV (US)
COELINGH BENNINK HERMAN JAN TI (NL)
COELINGH BENNINK HERMAN JAN TI (NL)
International Classes:
A61F6/06; A61K31/565; A61K45/06; A61K31/57; A61M31/00; A61M35/00; A61M37/00; A61P15/00; A61P15/18; (IPC1-7): A61K31/57; A61K31/565
Domestic Patent References:
| WO1994004156A1 | 1994-03-03 | |||
| WO1996015794A1 | 1996-05-30 | |||
| WO1993021927A1 | 1993-11-11 |
Foreign References:
| DE4330234A1 | 1995-03-09 | |||
| DE4344463A1 | 1995-06-29 | |||
| DE19531936A1 | 1997-02-20 |
Other References:
KEKKONEN R ET AL: "SEQUENTIAL REGIMEN OF THE ANTIPROGESTERONE RU486 AND SYNTHETIC PROGESTIN FOR CONTRACEPTION", FERTILITY AND STERILITY, vol. 60, no. 4, 1 October 1993 (1993-10-01), pages 610 - 615, XP000569447
WAGNER B L ET AL: "16ALPHA-SUBSTITUTED ANALOGS OF THE ANTIPROGESTIN RU486 INDUCE A UNIQUE CONFORMATION IN THE HUMAN PROGESTERONE RECEPTOR RESULTING IN MIXED AGONIST ACTIVITY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, no. 16, 6 August 1996 (1996-08-06), pages 8739 - 8744, XP002046549
BIOLOGICAL ABSTRACTS, vol. 1994, Philadelphia, PA, US; abstract no. 97453976, CHWALISZ KRISTOF: "The use of progesterone antagonists for cervical ripening and as an adjunct to labour and delivery." XP002103441
WAGNER B L ET AL: "16ALPHA-SUBSTITUTED ANALOGS OF THE ANTIPROGESTIN RU486 INDUCE A UNIQUE CONFORMATION IN THE HUMAN PROGESTERONE RECEPTOR RESULTING IN MIXED AGONIST ACTIVITY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, no. 16, 6 August 1996 (1996-08-06), pages 8739 - 8744, XP002046549
BIOLOGICAL ABSTRACTS, vol. 1994, Philadelphia, PA, US; abstract no. 97453976, CHWALISZ KRISTOF: "The use of progesterone antagonists for cervical ripening and as an adjunct to labour and delivery." XP002103441
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