Title:
PROGNOSTIC MARKERS IN LUNG CANCER, PROGNOSTIC TYPING MODEL OF LUNG CANCER, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/103905
Kind Code:
A1
Abstract:
Provided in the present application are prognostic markers in lung cancer, a prognostic typing model of lung cancer, and application thereof. The markers include imprinted genes Dcn, Peg10, Snrpn/Snurf and Trappc9. The four imprinted genes Dcn, Peg10, Snrpn/Snurf and Trappc9 of the present application have a significant correlation with prognosis of lung cancer. The imprinted gene Dcn is the most sensitive and specific marker of prognosis of lung cancer, which precedes clinicopathological features. A prognostic typing model of lung cancer can be constructed using the product of a total expression amount and a copy number variation expression amount of the four imprinted genes. The prognostic typing model of lung cancer can be used for personalized prediction of five-year survival time of lung cancer patients to provide accurate and useful prognostic information for the lung cancer patients.
Inventors:
CHENG TONG (CN)
ZHOU NING (CN)
ZHOU NING (CN)
Application Number:
PCT/CN2019/119966
Publication Date:
May 28, 2020
Filing Date:
November 21, 2019
Export Citation:
Assignee:
LISEN IMPRINTING DIAGNOSTICS INC (US)
LI XING (CN)
LI XING (CN)
International Classes:
C12Q1/6886; A61K48/00; A61P35/00; C12N15/11
Domestic Patent References:
| WO2007097741A1 | 2007-08-30 | |||
| WO2016154330A1 | 2016-09-29 | |||
| WO1995024503A1 | 1995-09-14 |
Other References:
XUAN HONG ET AL.: "Reduced decorin expression in the tumor stroma correlates with tumor proliferation and predicts poor prognosis in patients with I-IIIA non- small cell lung cancer", TUMOR BIOLOGY, vol. 37, no. 12, 10 October 2016 (2016-10-10), pages 16029 - 16038, XP036232789, ISSN: 1010-4283, DOI: 10.1007/s13277-016-5431-1
RONG, BIAOXUE ET AL.: "Study on expressions of Decorin mRNA, p57KIP2 mRNA and TGF-beta1 and their clinical significance in lung cancer", PRACTICAL GERIATRICS, vol. 25, no. 2, 30 April 2011 (2011-04-30), pages 137 - 139, XP009521388, DOI: 10.3969/j.issn.1003-9198.2011.02.014
XINZHOU DENG ET AL.: "PEG10 plays a crucial role in human lung cancer proliferation, progression, prognosis and metastasis", ONCOLOGY REPORTS, vol. 32, no. 5, 9 September 2014 (2014-09-09), pages 2159 - 2167, XP055554543, ISSN: 1021-335X, DOI: 10.3892/or.2014.3469
RONG, BIAOXUE ET AL.: "Study on expressions of Decorin mRNA, p57KIP2 mRNA and TGF-beta1 and their clinical significance in lung cancer", PRACTICAL GERIATRICS, vol. 25, no. 2, 30 April 2011 (2011-04-30), pages 137 - 139, XP009521388, DOI: 10.3969/j.issn.1003-9198.2011.02.014
XINZHOU DENG ET AL.: "PEG10 plays a crucial role in human lung cancer proliferation, progression, prognosis and metastasis", ONCOLOGY REPORTS, vol. 32, no. 5, 9 September 2014 (2014-09-09), pages 2159 - 2167, XP055554543, ISSN: 1021-335X, DOI: 10.3892/or.2014.3469
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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