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Title:
PROGRAMMABLE NUCLEOTIDE ENZYMES
Document Type and Number:
WIPO Patent Application WO/2015/187786
Kind Code:
A3
Abstract:
The present invention is directed to compositions and methods related to nucleotide enzymes, such as DNA Iigases. In one embodiment, principles of the present disclosure provide a composition comprising at least one or two or more nucleotide enzyme(s), wherein each of the nucleotide enzymes comprises at least a first and second target binding sequence and a catalytic sequence, wherein the first and second target binding sequences of the first and second nucleotide enzyme are substantially complementary to polynucleotide target sequences and wherein upon hybridization of polynucleotide target sequences with first and second target binding sequences of any of the nucleotide enzymes,

Inventors:
NAMIH CARINA (GB)
WENDELSTADT KATHARINA (BR)
SIWO GEOFFREY (US)
RAJANIEMI HANNU (US)
LOOS REMCO (GB)
MARTIN CRISTINA COTOBAL (GB)
SMALLIE TIM (GB)
Application Number:
PCT/US2015/033915
Publication Date:
January 28, 2016
Filing Date:
June 03, 2015
Export Citation:
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Assignee:
HELIX NANOTECHNOLOGIES INC (US)
International Classes:
C12N15/11
Domestic Patent References:
WO2008016644A12008-02-07
WO2013033792A12013-03-14
Foreign References:
US20110143338A12011-06-16
US20070072205A12007-03-29
US20060166222A12006-07-27
Other References:
LU ET AL.: "A Ligation-Triggered DNAzyme Cascade for Amplified Fluorescence Detection of Biological Small Molecules with Zero-Background Signal", J. AM. CHEM. SOC, vol. 133, 11 June 2011 (2011-06-11), pages 11686 - 11691, XP055238250, DOI: doi:10.1021/ja203693b
Attorney, Agent or Firm:
FOSTER, David C. (1400 Civic Place Suite 22, Southlake Texas US, US)
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