Title:
PROGRAMMABLE AND PRINTABLE BIOFILMS AS ENGINEERED LIVING MATERIALS
Document Type and Number:
WIPO Patent Application WO/2020/034914
Kind Code:
A1
Abstract:
Provided is a three-dimensional, living, self-regenerative structure of predetermined geometry, comprising solidified print material comprising a biofilm of Bacillus subtilis comprising a TasA-R protein, wherein R is a recombinant, heterologous functional group, wherein the TasA-R provides a preferably tunable physiochemical property like viscosity, reactivity, affinity as a function of the R group. A method of making the structure and a method of replicating the structure are also provided.
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Inventors:
ZHONG CHAO (CN)
HUANG JIAOFANG (CN)
LIU SUYING (CN)
ZHANG CHEN (CN)
HUANG JIAOFANG (CN)
LIU SUYING (CN)
ZHANG CHEN (CN)
Application Number:
PCT/CN2019/100160
Publication Date:
February 20, 2020
Filing Date:
August 12, 2019
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
International Classes:
C12N15/62; C12N15/75; C12R1/125
Domestic Patent References:
| WO2017201428A1 | 2017-11-23 | |||
| WO2000003018A2 | 2000-01-20 |
Foreign References:
| CN106754600A | 2017-05-31 | |||
| CN107998449A | 2018-05-08 |
Other References:
HUANG, J.F. ET AL.: "Programmable and printable Bacillus subtilis biofilms as engineered living materials", NATURE CHEMICAL BIOLOGY, vol. 15, no. 1, 3 December 2018 (2018-12-03), pages 34 - 41, XP036653749, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0169-2
CHEN, F. ET AL.: "Applications and perspectives of synthetic biology in biomaterials science", BIOTECHNOLOGY & BUSINESS, 31 January 2019 (2019-01-31), pages 10
CHEN, F. ET AL.: "Applications and perspectives of synthetic biology in biomaterials science", BIOTECHNOLOGY & BUSINESS, 31 January 2019 (2019-01-31), pages 10
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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