Title:
PROGRAMMING LIVING GLUE SYSTEMS TO PERFORM AUTONOMOUS MECHANICAL REPAIRS
Document Type and Number:
WIPO Patent Application WO/2022/052745
Kind Code:
A1
Abstract:
A living engineered glue system for performing autonomous mechanical repairs comprises a biofilm of microbial cells embedded in an extracellular matrix and operably linked in an environmentally-inducible, cell-cell communication genetic circuit to control gene expression.
Inventors:
ZHONG CHAO (CN)
AN BOLIN (CN)
WANG YANYI (CN)
JIANG XIAOYU (CN)
AN BOLIN (CN)
WANG YANYI (CN)
JIANG XIAOYU (CN)
Application Number:
PCT/CN2021/112745
Publication Date:
March 17, 2022
Filing Date:
August 16, 2021
Export Citation:
Assignee:
UNIV SHANGHAI TECH (CN)
International Classes:
C09J7/10; C07K19/00; C09J105/00; C12N15/13; C12N15/75
Domestic Patent References:
| WO2019228291A1 | 2019-12-05 | |||
| WO2016149074A1 | 2016-09-22 |
Foreign References:
| CN108753183A | 2018-11-06 | |||
| CN106754600A | 2017-05-31 |
Other References:
ZHANG CHEN; HUANG JIAOFANG; ZHANG JICONG; LIU SUYING; CUI MENGKUI; AN BOLIN; WANG XINYU; PU JIAHUA; ZHAO TIANXIN; FAN CHUNHAI; LU : "Engineered Bacillus subtilis biofilms as living glues", MATERIALS TODAY, ELSEVIER, AMSTERDAM, NL, vol. 28, 19 January 2019 (2019-01-19), AMSTERDAM, NL , pages 40 - 48, XP085802855, ISSN: 1369-7021, DOI: 10.1016/j.mattod.2018.12.039
LOWERY NICK, MCNALLY LUKE, RATCLIFF WILLIAM, BROWN SAM, PARSEK MATTHEW: "Division of Labor, Bet Hedging, and the Evolution of Mixed Biofilm Investment Strategies", MBIO, vol. 8, no. 4, 8 August 2017 (2017-08-08), US , pages e00671 - 12, XP009535486, ISSN: 2150-7511, DOI: 10.1128/mBio.00672-17
CHAO ZHONG, THOMAS GURRY, ALLEN A. CHENG, JORDAN DOWNEY, ZHENGTAO DENG, COLLIN M. STULTZ, TIMOTHY K. LU: "Strong underwater adhesives made by self-assembling multi-protein nanofibres", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., vol. 9, no. 10, pages 858 - 866, XP055208249, ISSN: 17483387, DOI: 10.1038/nnano.2014.199
LOWERY NICK, MCNALLY LUKE, RATCLIFF WILLIAM, BROWN SAM, PARSEK MATTHEW: "Division of Labor, Bet Hedging, and the Evolution of Mixed Biofilm Investment Strategies", MBIO, vol. 8, no. 4, 8 August 2017 (2017-08-08), US , pages e00671 - 12, XP009535486, ISSN: 2150-7511, DOI: 10.1128/mBio.00672-17
CHAO ZHONG, THOMAS GURRY, ALLEN A. CHENG, JORDAN DOWNEY, ZHENGTAO DENG, COLLIN M. STULTZ, TIMOTHY K. LU: "Strong underwater adhesives made by self-assembling multi-protein nanofibres", NATURE NANOTECHNOLOGY, NATURE PUB. GROUP, INC., vol. 9, no. 10, pages 858 - 866, XP055208249, ISSN: 17483387, DOI: 10.1038/nnano.2014.199
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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