PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS

Title:

PROGRANULIN AS MARKER FOR AUTOIMMUNE DISORDERS

Document Type and Number:

WIPO Patent Application WO/2014/083040

Kind Code:

A3

Abstract:

The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder.

More Like This:

WO/1992/012245	HUMAN bFGF DERIVATIVES, THEIR ANALOGS AND PROCESS FOR THEIR PRODUCTION
JP2000513951	Title of Invention Relief of Cell Proliferation and Wound Treatment
WO/1998/031734	COMPOSITION AND METHOD FOR REGULATING THE ADHESION OF CELLS AND BIOMOLECULES TO HYDROPHOBIC SURFACES

Inventors:

PFREUNDSCHUH MICHAEL (DE)
PREUSS KLAUS-DIETER (DE)
THURNER LORENZ (DE)

Application Number:

PCT/EP2013/074829

Publication Date:

July 31, 2014

Filing Date:

November 27, 2013

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV SAARLAND (DE)

International Classes:

A61K38/00; A61K39/00; C07K14/47; C07K16/00; G01N33/564; G01N33/68

Other References:

THURNER LORENZ ET AL: "Progranulin antibodies in autoimmune diseases", JOURNAL OF AUTOIMMUNITY, vol. 42, 11 November 2012 (2012-11-11), pages 29 - 38, XP028531543, ISSN: 0896-8411, DOI: 10.1016/J.JAUT.2012.10.003
COMTESSE: "Technology Offer Progranulin as marker for autoimmune disorders BACKGROUND", 27 March 2013 (2013-03-27), XP055105611, Retrieved from the Internet [retrieved on 20140305]
LORENZ THURNER: "Abschluss-Bericht des Forschungsprojektes der klinischen Rotationstelle von Lorenz Thurner", 9 March 2013 (2013-03-09), XP055105614, Retrieved from the Internet [retrieved on 20140305]

Attorney, Agent or Firm:

WEINZIERL, Gerhard et al. (European Patent AttorneysLandsberger Str. 98, Munich, DE)

Download PDF:

View/Download PDF PDF Help

Previous Patent: DEVICE AND METHOD FOR DETERMINING RHEOLOGICAL PROPERTIES OF POLYMERISATION PRODUCT

Next Patent: SWITCHABLE DIRECTIONAL INFRARED RADIATION SOURCE