Title:
PROGRESSION INHIBITOR OR PROPHYLACTIC AGENT FOR ATHEROSCLEROSIS, BLOOD CHOLESTEROL LEVEL-LOWERING AGENT, AND FUNCTIONAL FOOD OR FOOD FOR SPECIFIED HEALTH USES
Document Type and Number:
WIPO Patent Application WO/2010/103837
Kind Code:
A1
Abstract:
Disclosed are a novel therapeutic agent and a novel prophylactic agent for atherosclerosis, a blood cholesterol level-lowering agent, and a functional food or a food for specified health uses effective for the inhibition and/or prevention of aging of blood vessels or inflammation in blood vessels. Specifically disclosed are an inhibitor of the progression of atherosclerosis, a prophylactic agent for atherosclerosis, a blood cholesterol level-lowering agent, and a functional food and a food for specified health uses both effective for the inhibition and/or prevention of aging of blood vessels or inflammation in blood vessels, each of which comprises, as an active ingredient, a hydrolysate of a collagen comprising at least one collagen tripeptide Gly-X-Y [wherein Gly-X-Y represents an amino acid sequence; and X and Y independently represent an amino acid residue other than Gly].
Inventors:
KATSUDA SHOGO (JP)
TANG LIHUA (JP)
SAKAI YASUO (JP)
TANG LIHUA (JP)
SAKAI YASUO (JP)
Application Number:
PCT/JP2010/001734
Publication Date:
September 16, 2010
Filing Date:
March 11, 2010
Export Citation:
Assignee:
JELLICE CO LTD (JP)
KANAZAWA MEDICAL UNIVERSITY (JP)
KATSUDA SHOGO (JP)
TANG LIHUA (JP)
SAKAI YASUO (JP)
KANAZAWA MEDICAL UNIVERSITY (JP)
KATSUDA SHOGO (JP)
TANG LIHUA (JP)
SAKAI YASUO (JP)
International Classes:
A61K38/17; A23L1/305; A61P3/06; A61P9/10; C07K5/062; C07K5/083
Foreign References:
| JP2003137807A | 2003-05-14 | |||
| JP2001031586A | 2001-02-06 | |||
| JPH1149802A | 1999-02-23 | |||
| JP2003048889A | 2003-02-21 | |||
| JP2004035475A | 2004-02-05 | |||
| JP2002275062A | 2002-09-25 | |||
| JP2005263758A | 2005-09-29 | |||
| JP2007182448A | 2007-07-19 | |||
| JP2002204687A | 2002-07-23 | |||
| JP2000102381A | 2000-04-11 | |||
| JP2004350513A | 2004-12-16 | |||
| JP2007231225A | 2007-09-13 | |||
| JP2005281186A | 2005-10-13 | |||
| JP2001031586A | 2001-02-06 |
Other References:
"The effects of the collagen tripeptide HACP on bone and tendon", FFI JOURNAL, vol. 210, September 2005 (2005-09-01), pages 854 - 858
K. MARUYAMA ET AL.: "The 12th Meeting of the Japanese Osteoarthitis Research Society"
STEHBENS WE: "Vascular Pathology", 1995, CHAPMAN AND HALL MEDICAL, article "Atherosclerosis and degenerative diseases of blood vessels", pages: 175 - 269
SHOGO KATSUDA: "From the standpoint of human pathology", ARTERIOSCLEROSIS, vol. 28, no. 3, 2001, pages 69 - 73
ROSS R: "The pathogenesis of atherosclerosis: a perspective for the 1990s", NATURE, vol. 362, 1993, pages 801 - 809, XP002087100, DOI: doi:10.1038/362801a0
TERUO WATANABE ET AL.: "Atherosclerosis", vol. 33, 1984, SOGO RINSHO, pages: 647 - 655
HUMBERT C, SANTISTEBAN M S, USSON Y, ROBERT-NICOUD M: "Intranuclear co-location of newly replicated DNA and PCNA by simultaneousimmunofluorescent labelling and confocal microscopy in MCF-7 cells", J CELL SCI, vol. 103, 1992, pages 97 - 103
KOYAMA H, RAINES EW, BOMFELDT KE, ROBERTS JM, ROSS R: "Fibrillarcollagen inhibits arterial smooth muscle cell proliferation through regulation ofCdk2 inhibitors", CELL, vol. 87, 1996, pages 1069 - 1078
ICHII T, KOYAMA H, TANAKA S, KIM S, SHIOI A, OKUNO Y, RAINES EW, IWAO H, OTANI S, NISHIZAWA Y.: "Fibrillar collagen specifically regulates human vascularsmooth muscle cell genes involved in cellular responses and the pericellularmatrix environment", CIRC RES., vol. 88, 2001, pages 460 - 467
ROSS R: "Atherosclerosis-An inflammatory disease", N ENGL J MED, vol. 340, 1999, pages 115 - 126
LIBBY P: "Molecular bases of the acute coronary syndrome", CIRCULATION, vol. 91, 1995, pages 2844 - 2850
MASANORI AIKAWA: "The stabilization of arteriosclerotic change by lipid- reducing treatments", EXPERIMENTAL MEDICINE, vol. 18, 2000, pages 145 - 151
See also references of EP 2407174A4
K. MARUYAMA ET AL.: "The 12th Meeting of the Japanese Osteoarthitis Research Society"
STEHBENS WE: "Vascular Pathology", 1995, CHAPMAN AND HALL MEDICAL, article "Atherosclerosis and degenerative diseases of blood vessels", pages: 175 - 269
SHOGO KATSUDA: "From the standpoint of human pathology", ARTERIOSCLEROSIS, vol. 28, no. 3, 2001, pages 69 - 73
ROSS R: "The pathogenesis of atherosclerosis: a perspective for the 1990s", NATURE, vol. 362, 1993, pages 801 - 809, XP002087100, DOI: doi:10.1038/362801a0
TERUO WATANABE ET AL.: "Atherosclerosis", vol. 33, 1984, SOGO RINSHO, pages: 647 - 655
HUMBERT C, SANTISTEBAN M S, USSON Y, ROBERT-NICOUD M: "Intranuclear co-location of newly replicated DNA and PCNA by simultaneousimmunofluorescent labelling and confocal microscopy in MCF-7 cells", J CELL SCI, vol. 103, 1992, pages 97 - 103
KOYAMA H, RAINES EW, BOMFELDT KE, ROBERTS JM, ROSS R: "Fibrillarcollagen inhibits arterial smooth muscle cell proliferation through regulation ofCdk2 inhibitors", CELL, vol. 87, 1996, pages 1069 - 1078
ICHII T, KOYAMA H, TANAKA S, KIM S, SHIOI A, OKUNO Y, RAINES EW, IWAO H, OTANI S, NISHIZAWA Y.: "Fibrillar collagen specifically regulates human vascularsmooth muscle cell genes involved in cellular responses and the pericellularmatrix environment", CIRC RES., vol. 88, 2001, pages 460 - 467
ROSS R: "Atherosclerosis-An inflammatory disease", N ENGL J MED, vol. 340, 1999, pages 115 - 126
LIBBY P: "Molecular bases of the acute coronary syndrome", CIRCULATION, vol. 91, 1995, pages 2844 - 2850
MASANORI AIKAWA: "The stabilization of arteriosclerotic change by lipid- reducing treatments", EXPERIMENTAL MEDICINE, vol. 18, 2000, pages 145 - 151
See also references of EP 2407174A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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