Title:
PROLIFERATION-ASSOCIATED MODULATION OF THE SPLICING OF THE INTEGRIN ALPHA 6 ISOFORMS
Document Type and Number:
WIPO Patent Application WO/2010/066046
Kind Code:
A8
Abstract:
This application relates to the use of agents such as expression vectors and nucleic acids encoding integrins α6 A or α6B as well as antibodies specific for those integrins which are capable of modulating the ratio between the B and A isoforms of the α6 integrin in the treatment of diseases associated with an altered proliferation rate, such as cancer. The application also relates to the use of the ratio between the B and A isoforms of the α6 integrin in the diagnosis of diseases associated with an altered proliferation rate.
Inventors:
BEAULIEU JEAN-FRANCOIS (CA)
HERRING ELIZABETH (CA)
BASORA NURIA (CA)
GROULX JEAN-FRANCOIS (CA)
HERRING ELIZABETH (CA)
BASORA NURIA (CA)
GROULX JEAN-FRANCOIS (CA)
Application Number:
PCT/CA2009/001802
Publication Date:
August 05, 2010
Filing Date:
December 10, 2009
Export Citation:
Assignee:
SOCPRA SCIENCES SANTE ET HUMAI (CA)
BEAULIEU JEAN-FRANCOIS (CA)
HERRING ELIZABETH (CA)
BASORA NURIA (CA)
GROULX JEAN-FRANCOIS (CA)
BEAULIEU JEAN-FRANCOIS (CA)
HERRING ELIZABETH (CA)
BASORA NURIA (CA)
GROULX JEAN-FRANCOIS (CA)
International Classes:
A61K48/00; A61K31/7088; A61K38/17; A61K45/00; A61P35/00; C12N15/63; C12N15/85; C12Q1/68; G01N33/567; G01N33/574; G01N33/68
Attorney, Agent or Firm:
OGILVY RENAULT LLP / S.E.N.C.R.L., s.r.l. (1 Place Ville MarieMontréal, Québec H3B 1R1, CA)
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