Title:
PROLIFERATIVE AGENT FOR BACTERIA OF GENUS FAECALIBACTERIUM
Document Type and Number:
WIPO Patent Application WO/2017/159647
Kind Code:
A1
Abstract:
[Problem] To provide a substance and method that are capable of effectively inducing proliferation in bacteria of the genus Faecalibacterium, thereby contributing to the prevention and treatment of diseases such as enterocolitis. [Solution] A proliferative agent for bacteria of the genus Faecalibacterium that contains 1-kestose as an active ingredient. In accordance with the present invention, proliferation can be effectively induced in bacteria of the genus Faecalibacterium both in vitro and in vivo. In particular, it is possible to simply and effectively increase in vivo proliferation of bacteria of the genus Faecalibacterium in humans and animals, with almost no concerns regarding side effects or safety. It is also possible to prevent or treat enterocolitis by increasing in vivo proliferation of bacteria of the genus Faecalibacterium in humans and animals.
Inventors:
TOCHIO TAKUMI (JP)
SATO FUYUHIKO (JP)
KONISHI KENTA (JP)
KOGA YASUHIRO (JP)
ENDO AKIHITO (JP)
SATO FUYUHIKO (JP)
KONISHI KENTA (JP)
KOGA YASUHIRO (JP)
ENDO AKIHITO (JP)
Application Number:
PCT/JP2017/010070
Publication Date:
September 21, 2017
Filing Date:
March 14, 2017
Export Citation:
Assignee:
B FOOD SCIENCE CO LTD (JP)
TOKAI MEDICAL TEST LABORATORY CO (JP)
TOKAI MEDICAL TEST LABORATORY CO (JP)
International Classes:
A61K31/702; A23L33/135; A61P1/04; C12N1/20
Foreign References:
| JP2007512840A | 2007-05-24 | |||
| JP2004049093A | 2004-02-19 | |||
| JP2013147469A | 2013-08-01 | |||
| JP2006321786A | 2006-11-30 | |||
| JP2005306781A | 2005-11-04 |
Other References:
SUZUKI, NOBUYUKI ET AL.: "Superiority of 1- kestose, the Smallest Fructo-oligosaccharide, to a Synthetic Mixture of Fructo- oligosaccharides in the Selective Stimulating Activity on Bifidobacteria", BIOSCIENCE AND MICROFLORA, vol. 25, no. 3, 2006, pages 109 - 116, XP055421270, ISSN: 1349-8355
KIHARA, MINORU ET AL.: "Production of short- chain fatty acids and gas from various oligosaccharides by gut microbes of carp (Cyprinus carpio L.) in micro-scale batch culture", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, vol. 132, no. 2, 2002, pages 333 - 340, XP055121442, ISSN: 1095-6433
MURAI, KENJI ET AL.: "Effect of Oral Administration to Rats of Various Undigestible Saccharides on Fecal pH, Water Contents and Enzyme Activities", BIFIDOBACTERIA AND MICROFLORA, vol. 13, no. 2, 1994, pages 91 - 98, XP055421280
KILIAN, STEPHANUS ET AL.: "The effects of the novel bifidogenic trisaccharide, neokestose, on the human colonic microbiota", SPRINGER FOR RESEARCH & DEVELOPMENT, vol. 18, no. 7, 1 October 2002 (2002-10-01), pages 637 - 644, XP055422858, ISSN: 1573-0972
BUYUKTORTOP, ASUMAN SAHIN ET AL.: "Determination and Comparison of Interaction Between Fructo- oligosaccharide Components and Lactobacillus acidophilus", SDU JOURNAL OF SCIENCE (E-JOURNAL), vol. 7, no. 1, 2012, pages 15 - 22, XP055577987, ISSN: 1306-7575
YASUNORI FUKUMORI ET AL.: "1-Kestose no Kinosei ni Tsuite (The effects of 1-Kestose on Physiological Funtions)", PROCEEDINGS OF THE RESEARCH SOCIETY OF JAPAN SUGAR REFINERIES' TECHNOLOGISTS, vol. 52, 1 January 2004 (2004-01-01), pages 13 - 18, XP003021026, ISSN: 0370-9841
See also references of EP 3431090A4
KIHARA, MINORU ET AL.: "Production of short- chain fatty acids and gas from various oligosaccharides by gut microbes of carp (Cyprinus carpio L.) in micro-scale batch culture", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, vol. 132, no. 2, 2002, pages 333 - 340, XP055121442, ISSN: 1095-6433
MURAI, KENJI ET AL.: "Effect of Oral Administration to Rats of Various Undigestible Saccharides on Fecal pH, Water Contents and Enzyme Activities", BIFIDOBACTERIA AND MICROFLORA, vol. 13, no. 2, 1994, pages 91 - 98, XP055421280
KILIAN, STEPHANUS ET AL.: "The effects of the novel bifidogenic trisaccharide, neokestose, on the human colonic microbiota", SPRINGER FOR RESEARCH & DEVELOPMENT, vol. 18, no. 7, 1 October 2002 (2002-10-01), pages 637 - 644, XP055422858, ISSN: 1573-0972
BUYUKTORTOP, ASUMAN SAHIN ET AL.: "Determination and Comparison of Interaction Between Fructo- oligosaccharide Components and Lactobacillus acidophilus", SDU JOURNAL OF SCIENCE (E-JOURNAL), vol. 7, no. 1, 2012, pages 15 - 22, XP055577987, ISSN: 1306-7575
YASUNORI FUKUMORI ET AL.: "1-Kestose no Kinosei ni Tsuite (The effects of 1-Kestose on Physiological Funtions)", PROCEEDINGS OF THE RESEARCH SOCIETY OF JAPAN SUGAR REFINERIES' TECHNOLOGISTS, vol. 52, 1 January 2004 (2004-01-01), pages 13 - 18, XP003021026, ISSN: 0370-9841
See also references of EP 3431090A4
Attorney, Agent or Firm:
SAGAWA Shingo et al. (JP)
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