Title:
PROLYL HYDROXYLASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2010/022307
Kind Code:
A3
Abstract:
The invention described herein relates to certain bicyclic heteroaromatic N-substituted glycine derivatives of formula (I), which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Inventors:
SHAW ANTONY N (US)
TEDESCO ROSANNA (US)
TEDESCO ROSANNA (US)
Application Number:
PCT/US2009/054573
Publication Date:
April 22, 2010
Filing Date:
August 21, 2009
Export Citation:
Assignee:
GLAXOSMITHKLINE LLC (US)
SHAW ANTONY N (US)
TEDESCO ROSANNA (US)
SHAW ANTONY N (US)
TEDESCO ROSANNA (US)
International Classes:
A01N43/54
Domestic Patent References:
| WO2008089051A1 | 2008-07-24 | |||
| WO2007038571A2 | 2007-04-05 |
Other References:
MCDONOUGH ET AL.: "Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)", PNAS, vol. 103, no. 26, 27 June 2006 (2006-06-27), pages 9814 - 9819, XP002432975
Attorney, Agent or Firm:
GIMMI, Edward, R. et al. (Corporate Intellectual Property UW2220,709 Swedeland Road, P.O. Box 153, King of Prussia PA, US)
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