Title:
PROMOTER CAPABLE OF PROMOTING INHIBITION OF EXPRESSION OF MRNA BY RNA INTERFERENCE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/051459
Kind Code:
A1
Abstract:
Provided is a promoter capable of promoting the inhibition of the expression of mRNA by RNA interference.
The promoter according to the present invention is characterized by comprising at least one active ingredient selected from the group consisting of resveratrol, a resveratrol derivative, a tautomer, a geometric isomer and a stereoisomer of resveratrol or the resveratrol derivative, and salts thereof, wherein the active ingredient can promote the transcription of a nucleic acid capable of inhibiting the expression of mRNA by RNA interference and/or the expression of Argonaute-2 (Ago2). The nucleic acid is preferably miRNA. The promoter according to the present invention is applicable to, for example, a method for treating a disease utilizing RNA interference, a medicinal agent, a food additive, the analysis of a gene by means of knock down, and others
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Inventors:
OCHIYA TAKAHIRO (JP)
Application Number:
PCT/JP2012/074921
Publication Date:
April 11, 2013
Filing Date:
September 27, 2012
Export Citation:
Assignee:
KEWPIE CORP (JP)
International Classes:
A61K31/05; A61K31/015; A61K48/00; A61P3/10; A61P25/28; A61P35/00; A61P43/00; C12N15/09; A23L1/30
Foreign References:
| JP2009500357A | 2009-01-08 | |||
| JP2011132147A | 2011-07-07 | |||
| JP2007126390A | 2007-05-24 | |||
| JP2006273834A | 2006-10-12 | |||
| JP2009531421A | 2009-09-03 | |||
| JP2010538077A | 2010-12-09 |
Other References:
TILI, E. ET AL.: "Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGF P signaling pathway in SW480 cells", BIOCHEM PHARMACOL, vol. 80, no. 12, 2010, pages 2057 - 65, XP027456072
DHAR, S. ET AL.: "Resveratrol and prostate cancer: promising role for microRNAs", MOL NUTR FOOD RES, vol. 55, no. 8, August 2011 (2011-08-01), pages 1219 - 29, XP055064682
BAE, S. ET AL ET AL.: "Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells", MOL CELLS, vol. 32, no. 3, September 2011 (2011-09-01), pages 243 - 9, XP055064683
RIMANDO, A.M. ET AL.: "Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol", J AGRIC FOOD CHEM, vol. 50, no. 12, 2002, pages 3453 - 7, XP002968963
ANEKONDA, T.S.: "Resveratrol--a boon for treating Alzheimer's disease?", BRAIN RES REV, vol. 52, no. 2, 2006, pages 316 - 26, XP002615355
MARAMBAUD, P. ET AL.: "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides", J BIOL CHEM, vol. 280, no. 45, 2005, pages 37377 - 82, XP008104130
DHAR, S. ET AL.: "Resveratrol and prostate cancer: promising role for microRNAs", MOL NUTR FOOD RES, vol. 55, no. 8, August 2011 (2011-08-01), pages 1219 - 29, XP055064682
BAE, S. ET AL ET AL.: "Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells", MOL CELLS, vol. 32, no. 3, September 2011 (2011-09-01), pages 243 - 9, XP055064683
RIMANDO, A.M. ET AL.: "Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol", J AGRIC FOOD CHEM, vol. 50, no. 12, 2002, pages 3453 - 7, XP002968963
ANEKONDA, T.S.: "Resveratrol--a boon for treating Alzheimer's disease?", BRAIN RES REV, vol. 52, no. 2, 2006, pages 316 - 26, XP002615355
MARAMBAUD, P. ET AL.: "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides", J BIOL CHEM, vol. 280, no. 45, 2005, pages 37377 - 82, XP008104130
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
Koichiro Tsujimaru (JP)
Koichiro Tsujimaru (JP)
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