Title:
PROMOTER OF DIFFERENTIATION OF PLURIPOTENT STEM CELL INTO MYOCARDIUM, WHICH COMPRISES EGF RECEPTOR INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/136519
Kind Code:
A1
Abstract:
The present invention provides a promoter of the differentiation of a pluripotent stem cell into a myocardium, which comprises an EGF receptor inhibitor. The present invention also provides: a kit for promoting the differentiation into a myocardium, which comprises an EGF receptor inhibitor; and a method for inducing the differentiation of a pluripotent stem cell into a myocardium, which comprises culturing the pluripotent stem cell in a culture medium containing an EGF receptor inhibitor.
More Like This:
Inventors:
NAKATSUJI NORIO (JP)
MINAMI ITSUNARI (JP)
MINAMI ITSUNARI (JP)
Application Number:
PCT/JP2014/052673
Publication Date:
September 12, 2014
Filing Date:
February 05, 2014
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/07; C12N5/0735; C12N5/10
Domestic Patent References:
| WO2012026491A1 | 2012-03-01 | |||
| WO2013111875A1 | 2013-08-01 | |||
| WO2011071118A1 | 2011-06-16 | |||
| WO2012026491A1 | 2012-03-01 | |||
| WO2007069666A1 | 2007-06-21 | |||
| WO2009006930A1 | 2009-01-15 | |||
| WO2009006997A1 | 2009-01-15 | |||
| WO2009007852A2 | 2009-01-15 | |||
| WO2008118820A2 | 2008-10-02 |
Foreign References:
| US20100183565A1 | 2010-07-22 | |||
| JP2000508919A | 2000-07-18 |
Other References:
SHEN, G. ET AL., A 2,6-DISUBSTITUTED 4-ANILINOQUINAZOLINE DERIVATIVE FACILITATES CARDIOMYOGENESIS OF EMBRYONIC STEM CELLS, CHEMMEDCHEM, vol. 7, 2012, pages 733 - 740, XP055240274
TAKAYUKI MORISAKI: "Shinkin Bunka ni Okeru Bunshi Kaibogakuteki Seigyo Kiko no Kaimei ni Kansuru Kenkyu", ANNUAL REPORT OF THE RESEARCH ON CARDIOVASCULAR DISEASES (HEISEI 15 NENDO), NATIONAL CARDIOVASCULAR CENTER, January 2005 (2005-01-01), pages 177, XP008181719
WANG, Z. ET AL.: "Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells", MED. BIOL. ENG. COMPUT., vol. 47, 2009, pages 41 - 48, XP019835287
MINAMI, I. ET AL., A SMALL MOLECULE THAT PROMOTES CARDIAC DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED, CYTOKINE- AND XENO-FREE CONDITIONS, CELL REPORTS, vol. 2, 2012, pages 1448 - 1460, XP055097336
ITSUNARI MINAMI ET AL.: "Shinki Teibunshi Kagobutsu o Mochiita Hito ES /iPS Saibo no Rinsho Grade Shinkin Bunka Yudoho no Kaihatsu", REGENERATIVE MEDICINE, vol. 12, 28 February 2013 (2013-02-28), pages 151, XP008181336
WANG HANMIN ET AL.: "Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt/beta-Catenin Signaling", ACS CHEM. BIOL., vol. 6, 2011, pages 192 - 197, XP055159413
MUMMERY, C. ET AL.: "Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells", CIRCULATION, vol. 107, no. 21, 2003, pages 2733 - 40, XP008029536, DOI: doi:10.1161/01.CIR.0000068356.38592.68
YANG, L. ET AL.: "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population", NATURE, vol. 453, no. 7194, 2008, pages 524 - 8, XP002561095, DOI: doi:10.1038/nature06894
LESCHIK, J. ET AL.: "Cardiac commitment of primate embryonic stem cells", NAT PROTOC., vol. 3, no. 9, 2008, pages 1381 - 7, XP001538578, DOI: doi:10.1038/nprot.2008.116
PAUL, W B. ET AL.: "A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability", PLOSONE, vol. 6, no. 4, 2011, pages EL8293, XP009167975, DOI: doi:10.1371/journal.pone.0018293
WANG, H. ET AL.: "Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/?-catenin signaling", ACS CHEM BIOL., vol. 6, no. 2, 2011, pages 192 - 7, XP055159413, DOI: doi:10.1021/cb100323z
IWAMOTO, R. ET AL.: "Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function", PROC NATL ACAD SCI U S A., vol. 100, no. 6, 2003, pages 3221 - 6, XP002972137, DOI: doi:10.1073/pnas.0537588100
MINAMI, I. ET AL.: "A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions", CELL REP, vol. 2, no. 5, 25 October 2012 (2012-10-25), pages 1448 - 60, XP055097336, DOI: doi:10.1016/j.celrep.2012.09.015
THOMSON J. A. ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
BIOCHEM BIOPHYS RES COMMUN, vol. 345, no. 3, 2006, pages 926 - 32
THOMSON J. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 7844 - 7848
THOMSON J. A. ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
DOETSHMAN T. ET AL., DEV. BIOL., vol. 127, 1988, pages 224 - 227
EVANS M. J. ET AL., THERIOGENOLOGY, vol. 33, 1990, pages 125128
PIEDRAHITA J. A. ET AL., THERIOGENOLOGY, vol. 34, 1990, pages 879 - 891
NOTARIANNI E. ET AL., J. REPROD. FERT., vol. 40, 1990, pages 51 - 56
TALBOT N. C. ET AL., CELL. DEV. BIOL., vol. 29A, 1993, pages 546 - 554
NOTARIANNI E. ET AL., J. REPROD. FERT., 1991, pages 255 - 260
EVANS M. J. ET AL., THERIOGENOLOGY, vol. 33, 1990, pages 125 - 128
SAITO S. ET AL., ROUX. ARCH. DEV. BIOL., vol. 201, 1992, pages 134 - 141
SUKOYAN M. A. ET AL., MOL. REOROD. DEV., vol. 33, 1993, pages 418 - 431
SHAMBLOTT ET AL., PROC. NATL. ACAD. SCI USA, vol. 95, 1998, pages 13726 - 13731
CELL STEM CELL, vol. 3, no. 5, 2008, pages 568 - 574
CELL STEM CELL, vol. 4, no. 5, 2009, pages 381 - 384
NATURE, vol. 454, 2008, pages 646 - 650
CELL, vol. 136, no. 3, 2009, pages 411 - 419
NATURE BIOTECHNOLOGY, vol. 26, 2008, pages 1269 - 1275
CELL STEM CELL, vol. 3, 2008, pages 475 - 479
NATURE CELL BIOLOGY, vol. 11, 2009, pages 197 - 203
CELL, vol. 133, no. 2, 2008, pages 250 - 264
CELL, vol. 131, no. 5, 2007, pages 861 - 72
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 20
J. MED. CHEM., vol. 8, no. 5, 1965, pages 734 - 735
TAKAYUKI MORISAKI: "Shinkin Bunka ni Okeru Bunshi Kaibogakuteki Seigyo Kiko no Kaimei ni Kansuru Kenkyu", ANNUAL REPORT OF THE RESEARCH ON CARDIOVASCULAR DISEASES (HEISEI 15 NENDO), NATIONAL CARDIOVASCULAR CENTER, January 2005 (2005-01-01), pages 177, XP008181719
WANG, Z. ET AL.: "Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells", MED. BIOL. ENG. COMPUT., vol. 47, 2009, pages 41 - 48, XP019835287
MINAMI, I. ET AL., A SMALL MOLECULE THAT PROMOTES CARDIAC DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED, CYTOKINE- AND XENO-FREE CONDITIONS, CELL REPORTS, vol. 2, 2012, pages 1448 - 1460, XP055097336
ITSUNARI MINAMI ET AL.: "Shinki Teibunshi Kagobutsu o Mochiita Hito ES /iPS Saibo no Rinsho Grade Shinkin Bunka Yudoho no Kaihatsu", REGENERATIVE MEDICINE, vol. 12, 28 February 2013 (2013-02-28), pages 151, XP008181336
WANG HANMIN ET AL.: "Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt/beta-Catenin Signaling", ACS CHEM. BIOL., vol. 6, 2011, pages 192 - 197, XP055159413
MUMMERY, C. ET AL.: "Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells", CIRCULATION, vol. 107, no. 21, 2003, pages 2733 - 40, XP008029536, DOI: doi:10.1161/01.CIR.0000068356.38592.68
YANG, L. ET AL.: "Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population", NATURE, vol. 453, no. 7194, 2008, pages 524 - 8, XP002561095, DOI: doi:10.1038/nature06894
LESCHIK, J. ET AL.: "Cardiac commitment of primate embryonic stem cells", NAT PROTOC., vol. 3, no. 9, 2008, pages 1381 - 7, XP001538578, DOI: doi:10.1038/nprot.2008.116
PAUL, W B. ET AL.: "A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability", PLOSONE, vol. 6, no. 4, 2011, pages EL8293, XP009167975, DOI: doi:10.1371/journal.pone.0018293
WANG, H. ET AL.: "Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/?-catenin signaling", ACS CHEM BIOL., vol. 6, no. 2, 2011, pages 192 - 7, XP055159413, DOI: doi:10.1021/cb100323z
IWAMOTO, R. ET AL.: "Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function", PROC NATL ACAD SCI U S A., vol. 100, no. 6, 2003, pages 3221 - 6, XP002972137, DOI: doi:10.1073/pnas.0537588100
MINAMI, I. ET AL.: "A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions", CELL REP, vol. 2, no. 5, 25 October 2012 (2012-10-25), pages 1448 - 60, XP055097336, DOI: doi:10.1016/j.celrep.2012.09.015
THOMSON J. A. ET AL., SCIENCE, vol. 282, 1998, pages 1145 - 1147
BIOCHEM BIOPHYS RES COMMUN, vol. 345, no. 3, 2006, pages 926 - 32
THOMSON J. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 7844 - 7848
THOMSON J. A. ET AL., BIOL. REPROD., vol. 55, 1996, pages 254 - 259
DOETSHMAN T. ET AL., DEV. BIOL., vol. 127, 1988, pages 224 - 227
EVANS M. J. ET AL., THERIOGENOLOGY, vol. 33, 1990, pages 125128
PIEDRAHITA J. A. ET AL., THERIOGENOLOGY, vol. 34, 1990, pages 879 - 891
NOTARIANNI E. ET AL., J. REPROD. FERT., vol. 40, 1990, pages 51 - 56
TALBOT N. C. ET AL., CELL. DEV. BIOL., vol. 29A, 1993, pages 546 - 554
NOTARIANNI E. ET AL., J. REPROD. FERT., 1991, pages 255 - 260
EVANS M. J. ET AL., THERIOGENOLOGY, vol. 33, 1990, pages 125 - 128
SAITO S. ET AL., ROUX. ARCH. DEV. BIOL., vol. 201, 1992, pages 134 - 141
SUKOYAN M. A. ET AL., MOL. REOROD. DEV., vol. 33, 1993, pages 418 - 431
SHAMBLOTT ET AL., PROC. NATL. ACAD. SCI USA, vol. 95, 1998, pages 13726 - 13731
CELL STEM CELL, vol. 3, no. 5, 2008, pages 568 - 574
CELL STEM CELL, vol. 4, no. 5, 2009, pages 381 - 384
NATURE, vol. 454, 2008, pages 646 - 650
CELL, vol. 136, no. 3, 2009, pages 411 - 419
NATURE BIOTECHNOLOGY, vol. 26, 2008, pages 1269 - 1275
CELL STEM CELL, vol. 3, 2008, pages 475 - 479
NATURE CELL BIOLOGY, vol. 11, 2009, pages 197 - 203
CELL, vol. 133, no. 2, 2008, pages 250 - 264
CELL, vol. 131, no. 5, 2007, pages 861 - 72
SCIENCE, vol. 318, no. 5858, 2007, pages 1917 - 20
J. MED. CHEM., vol. 8, no. 5, 1965, pages 734 - 735
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
Download PDF: