Title:
PROMOTER EXHIBITING HIGH EXPRESSION ACTIVITY IN MORTIERELLA MICROORGANISMS
Document Type and Number:
WIPO Patent Application WO/2014/157736
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a promoter exhibiting high expression activity in Mortierella microorganisms. Accordingly, the present invention provides: a polynucleotide including any one base sequence selected from the group consisting of SEQ ID NO. 1-28; or a mutant thereof.
Inventors:
OCHIAI MISA (JP)
OGAWA JUN (JP)
SAKURADANI EIJI (JP)
ANDO AKINORI (JP)
OGAWA JUN (JP)
SAKURADANI EIJI (JP)
ANDO AKINORI (JP)
Application Number:
PCT/JP2014/059698
Publication Date:
October 02, 2014
Filing Date:
March 26, 2014
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
C12N15/09; C12N1/15; C12N15/11; C12P7/64; C12R1/645
Domestic Patent References:
| WO2005019437A1 | 2005-03-03 |
Foreign References:
| JP2005287403A | 2005-10-20 |
Other References:
MACKENZIE D.A. ET AL.: "Isolation and use of a homologous histone H4 promoter and a ribosomal DNA region in a transformation vector for the oil-producing fungus Mortierella alpina", APPL. ENVIRON.MICROBIOL., vol. 66, no. 11, 2000, pages 4655 - 61, XP002291019
MULLER S. ET AL.: "Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica", YEAST, vol. 14, no. 14, 1998, pages 1267 - 83, XP055291459
BLAZECK J. ET AL.: "Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach", APPL.ENVIRON.MICROBIOL., vol. 77, no. 22, 2011, pages 7905 - 14, XP055291461
AMARASINGHE B.H.R.R. ET AL.: "Genomic approaches to the discovery of promoters for sustained expression in cotton (Gossypium hirsutum L.) under field conditions: expression analysis in transgenic cotton and Arabidopsis of a Rubisco small subunit promoter identified using EST sequence analysis and cDNA microarrays", PLANT BIOTECHNOL., vol. 23, no. 5, 2006, pages 437 - 50, XP055291462
OKUDA T. ET AL.: "Selection and characterization of promoters based on genomic approach for the molecular breeding of oleaginous fungus Mortierella alpina 1S-4", CURR.GENET., February 2014 (2014-02-01), XP055291463
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR, LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
MYCOTAXON, vol. XLIV, no. 2, 1992, pages 257 - 265
APPL. MICROBIOL. BIOTECHNOL., vol. 65, 2004, pages 419 - 425
APPL. ENVIRON. MICROBIOL., vol. 75, 2009, pages 5529 - 5535
APPL. ENVIRON. MICROBIOL., vol. 66, no. 11, November 2000 (2000-11-01), pages 4655 - 4661
J. BIOSCI. BIOENG., vol. 100, no. 6, December 2005 (2005-12-01), pages 617 - 622
CURR. GENET., vol. 55, no. 3, 2009, pages 349 - 356
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
PETER J. PUNT; CEES A.M.J.J.; VAN DEN HONDEL: "Transformation of filamentous fungi based on hygromycin b and phleomycin resistance markers", METHODS IN ENZYMOLOGY, vol. 216, 1992, pages 447 - 457, XP000985888, DOI: doi:10.1016/0076-6879(92)16041-H
AVALOS, J.; GEEVER, R. F.; CASE, M. E.: "Bialaphos resistance as a dominant selectable marker in Neurospora crassa", CURR. GENET., vol. 16, 1989, pages 369 - 372
ZHANG, S.; FAN, Y.; XIA, YX.; KEYHANI, N.O: "Sulfonylurea resistance as a new selectable marker for the entomopathogenic fungus Beauveria bassiana", APPL MICROBIOL BIOTECHNOL, vol. 87, 2010, pages 1151 - 1156, XP019841634
KOENRAADT, H.; S. C. SOMMERVILLE; A. L. JONES.: "Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturia inaequalis and other pathogenic fungi", MOL. PLANT PATHOL., vol. 82, 1992, pages 1348 - 1354
KELLY, J. M.; HYNES, M. J: "Transformation of Aspergillus niger by the Eamds gene of Aspergillus nidulans", EMBO J., vol. 4, 1985, pages 475 - 479
MACKENXIE D. A. ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, COLD SPRING HARBOR LABORATORY PRESS
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2980216A4
MULLER S. ET AL.: "Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica", YEAST, vol. 14, no. 14, 1998, pages 1267 - 83, XP055291459
BLAZECK J. ET AL.: "Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach", APPL.ENVIRON.MICROBIOL., vol. 77, no. 22, 2011, pages 7905 - 14, XP055291461
AMARASINGHE B.H.R.R. ET AL.: "Genomic approaches to the discovery of promoters for sustained expression in cotton (Gossypium hirsutum L.) under field conditions: expression analysis in transgenic cotton and Arabidopsis of a Rubisco small subunit promoter identified using EST sequence analysis and cDNA microarrays", PLANT BIOTECHNOL., vol. 23, no. 5, 2006, pages 437 - 50, XP055291462
OKUDA T. ET AL.: "Selection and characterization of promoters based on genomic approach for the molecular breeding of oleaginous fungus Mortierella alpina 1S-4", CURR.GENET., February 2014 (2014-02-01), XP055291463
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR, LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
MYCOTAXON, vol. XLIV, no. 2, 1992, pages 257 - 265
APPL. MICROBIOL. BIOTECHNOL., vol. 65, 2004, pages 419 - 425
APPL. ENVIRON. MICROBIOL., vol. 75, 2009, pages 5529 - 5535
APPL. ENVIRON. MICROBIOL., vol. 66, no. 11, November 2000 (2000-11-01), pages 4655 - 4661
J. BIOSCI. BIOENG., vol. 100, no. 6, December 2005 (2005-12-01), pages 617 - 622
CURR. GENET., vol. 55, no. 3, 2009, pages 349 - 356
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
PETER J. PUNT; CEES A.M.J.J.; VAN DEN HONDEL: "Transformation of filamentous fungi based on hygromycin b and phleomycin resistance markers", METHODS IN ENZYMOLOGY, vol. 216, 1992, pages 447 - 457, XP000985888, DOI: doi:10.1016/0076-6879(92)16041-H
AVALOS, J.; GEEVER, R. F.; CASE, M. E.: "Bialaphos resistance as a dominant selectable marker in Neurospora crassa", CURR. GENET., vol. 16, 1989, pages 369 - 372
ZHANG, S.; FAN, Y.; XIA, YX.; KEYHANI, N.O: "Sulfonylurea resistance as a new selectable marker for the entomopathogenic fungus Beauveria bassiana", APPL MICROBIOL BIOTECHNOL, vol. 87, 2010, pages 1151 - 1156, XP019841634
KOENRAADT, H.; S. C. SOMMERVILLE; A. L. JONES.: "Characterization of mutations in the beta-tubulin gene of benomyl-resistant field strains of Venturia inaequalis and other pathogenic fungi", MOL. PLANT PATHOL., vol. 82, 1992, pages 1348 - 1354
KELLY, J. M.; HYNES, M. J: "Transformation of Aspergillus niger by the Eamds gene of Aspergillus nidulans", EMBO J., vol. 4, 1985, pages 475 - 479
MACKENXIE D. A. ET AL., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, COLD SPRING HARBOR LABORATORY PRESS
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2980216A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
Download PDF:
Previous Patent: PLANARIZATION METHOD, SUBSTRATE PROCESSING SYSTEM, AND MEMORY MANUFACTURING METHOD
Next Patent: PROCESS FOR PRODUCING POLARIZING FILM
Next Patent: PROCESS FOR PRODUCING POLARIZING FILM