Title:
PROMOTER FOR REGENERATION OF TENDON-BONE JUNCTION TISSUE OR LIGAMENT-BONE JUNCTION TISSUE
Document Type and Number:
WIPO Patent Application WO/2010/041716
Kind Code:
A1
Abstract:
Disclosed is an agent for promoting the regeneration of a tendon-bone junction tissue or a ligament-bone junction tissue. Specifically disclosed is a promoter for the regeneration of a tendon-bone junction tissue or a ligament-bone junction tissue, which is characterized by comprising the following component (1) or (2) as an active ingredient.
(1) A component selected from the following items (1-a), (1-b) and (1-c): (1-a) an HGF protein; (1-b) a partial peptide of an HGF protein, wherein the peptide has an activity to promote the regeneration of a tendon-bone junction tissue or a ligament-bone junction tissue; and (1-c) a salt of the component (1-a) or (1-b).
(2) DNA comprising a component selected from the following items (2-a), (2-b) and (2-c): (2-a) DNA encoding an HGF protein; (2-b) DNA encoding a partial peptide of an HGF protein, wherein the peptide has an activity to promote the regeneration of a tendon-bone junction tissue or a ligament-bone junction tissue; and (2-c) DNA which can hybridize with DNA comprising a nucleotide sequence complementary to DNA (2-a) or (2-b) under stringent conditions and encodes a protein or peptide having an activity to promote the regeneration of a tendon-bone junction tissue or a ligament-bone junction tissue.
Inventors:
TOMITA KATSURO (JP)
TSUCHIYA HIROYUKI (JP)
KITAOKA KATSUHIKO (JP)
NAKASE JUNSUKE (JP)
HANADA KEIGO (JP)
MATSUMOTO KUNIO (JP)
TSUCHIYA HIROYUKI (JP)
KITAOKA KATSUHIKO (JP)
NAKASE JUNSUKE (JP)
HANADA KEIGO (JP)
MATSUMOTO KUNIO (JP)
Application Number:
PCT/JP2009/067570
Publication Date:
April 15, 2010
Filing Date:
October 08, 2009
Export Citation:
Assignee:
KRINGLE PHARMA INC (JP)
TOMITA KATSURO (JP)
TSUCHIYA HIROYUKI (JP)
KITAOKA KATSUHIKO (JP)
NAKASE JUNSUKE (JP)
HANADA KEIGO (JP)
MATSUMOTO KUNIO (JP)
TOMITA KATSURO (JP)
TSUCHIYA HIROYUKI (JP)
KITAOKA KATSUHIKO (JP)
NAKASE JUNSUKE (JP)
HANADA KEIGO (JP)
MATSUMOTO KUNIO (JP)
International Classes:
A61K38/22; A61K48/00; A61P19/04
Domestic Patent References:
| WO2008105507A1 | 2008-09-04 |
Foreign References:
| JPH05111382A | 1993-05-07 | |||
| JPH111499A | 1999-01-06 | |||
| JP2777678B2 | 1998-07-23 | |||
| JPH06128521A | 1994-05-10 | |||
| US6913923B2 | 2005-07-05 |
Other References:
SANCHEZ, M. ET AL.: "Comparison of surgically repaired Achilles tendon tears using platelet- rich fibrin matrices.", AM. J. SPORTS MED., vol. 35, 2007, pages 245 - 51, XP008100254
TAKASHI NATSUUME ET AL.: "Kan Saibo Zoshoku Inshi Idenshi Donyu no Ken Shufuku ni Taisuru Shoki Koka: Rat Shitsugai Ken Sonsho Model ni Okeru Kento", J. JPN. ORTHOP. ASSOC., vol. 72, 1998, pages S1254, XP008139953
YAMAZAKI, S. ET AL.: "The effect of transforming growth factor-betal on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs.", ARTHROSCOPY, vol. 21, 2005, pages 1034 - 41, XP005079330
MA, C.B. ET AL.: "Bone morphogenetic proteins- signaling plays a role in tendon-to-bone healing: a study of rhBMP-2 and noggin.", AM. J. SPORTS MED., vol. 35, 2007, pages 597 - 604, XP008139963
HSU, C. ET AL.: "Clinical implications of growth factors in flexor tendon wound healing.", J. HAND SURG. AM., vol. 29, 2004, pages 551 - 63, XP002479466
LIN, T.W. ET AL.: "Biomechanics of tendon injury and repair.", J. BIOMECH., vol. 37, 2004, pages 865 - 77, XP008139402
JIANG, D. ET AL.: "HGF suppresses the production of collagen type III and alpha-SMA induced by TGF-betal in healing fibroblasts", EUR. J. APPL. PHYSIOL., vol. 103, July 2008 (2008-07-01), pages 489 - 93, XP019630044
See also references of EP 2351574A4
S.A. RODEO ET AL.: "The Journal of Bone and Joint Surgery", JBJS, vol. 75-A, no. 12, 1993, pages 1795 - 1803
S.A. RODEO ET AL., THE AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 27, 1999, pages 476 - 488
SHUJI YAMAZAKI ET AL.: "The Journal of Arthroscopic and Related Surgery", JBJS, vol. 21, no. 9, 2005, pages 1034 - 1041
TOSHIKAZU NAKAMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 122, 1984, pages 1450 - 1459
TOSHIKAZU NAKAMURA ET AL., NATURE, vol. 342, 1989, pages 440 - 443
TAKASHI NATSU-UME ET AL., JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 72, no. 8, 1998, pages 1254
KUNIO MATSUMOTO, TOSHIKAZU NAKAMURA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 239, 1997, pages 639 - 644
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967
FUKUTA, K. ET AL., BIOCHEMICAL JOURNAL, vol. 388, 2005, pages 555 - 562
M. BODANSZKY, M. A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER, LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
NATURE, vol. 342, 1989, pages 440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967 - 973
PROC. NATL. ACAD. SCI. U.S.A., vol. 88, no. 16, 1991, pages 7001 - 7005
J. SAMBROOK ET AL.: "Molecular Cloning, A laboratory Manual", 2001, COLD SPRING HARBOR LAB. PRESS
"Experimental Medicine", 1996, YODOSHA CO., LTD., article "Idenshi Chiryo No Kiso-gijyutsu"
"Experimental Medicine", 1997, YODOSHA CO., LTD., article "Idenshi Dounyu & Hatsugen Kaiseki Jikken-hou"
"Idenshi Chiryo Kaihatsu Kenkyu Handbook", 1999, NTS INC.
COFFIN, R.S. ET AL., J. GEN. VIROL., vol. 79, 1998, pages 3019 - 3026
PALMER, J. A. ET AL., J. VIROL., vol. 74, 2000, pages 5604 - 5618
LILLEY, C. E. ET AL., J. VIROL., vol. 75, 2001, pages 4343 - 4356
TAKASHI NATSUUME ET AL.: "Kan Saibo Zoshoku Inshi Idenshi Donyu no Ken Shufuku ni Taisuru Shoki Koka: Rat Shitsugai Ken Sonsho Model ni Okeru Kento", J. JPN. ORTHOP. ASSOC., vol. 72, 1998, pages S1254, XP008139953
YAMAZAKI, S. ET AL.: "The effect of transforming growth factor-betal on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs.", ARTHROSCOPY, vol. 21, 2005, pages 1034 - 41, XP005079330
MA, C.B. ET AL.: "Bone morphogenetic proteins- signaling plays a role in tendon-to-bone healing: a study of rhBMP-2 and noggin.", AM. J. SPORTS MED., vol. 35, 2007, pages 597 - 604, XP008139963
HSU, C. ET AL.: "Clinical implications of growth factors in flexor tendon wound healing.", J. HAND SURG. AM., vol. 29, 2004, pages 551 - 63, XP002479466
LIN, T.W. ET AL.: "Biomechanics of tendon injury and repair.", J. BIOMECH., vol. 37, 2004, pages 865 - 77, XP008139402
JIANG, D. ET AL.: "HGF suppresses the production of collagen type III and alpha-SMA induced by TGF-betal in healing fibroblasts", EUR. J. APPL. PHYSIOL., vol. 103, July 2008 (2008-07-01), pages 489 - 93, XP019630044
See also references of EP 2351574A4
S.A. RODEO ET AL.: "The Journal of Bone and Joint Surgery", JBJS, vol. 75-A, no. 12, 1993, pages 1795 - 1803
S.A. RODEO ET AL., THE AMERICAN JOURNAL OF SPORTS MEDICINE, vol. 27, 1999, pages 476 - 488
SHUJI YAMAZAKI ET AL.: "The Journal of Arthroscopic and Related Surgery", JBJS, vol. 21, no. 9, 2005, pages 1034 - 1041
TOSHIKAZU NAKAMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 122, 1984, pages 1450 - 1459
TOSHIKAZU NAKAMURA ET AL., NATURE, vol. 342, 1989, pages 440 - 443
TAKASHI NATSU-UME ET AL., JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 72, no. 8, 1998, pages 1254
KUNIO MATSUMOTO, TOSHIKAZU NAKAMURA, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 239, 1997, pages 639 - 644
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967
FUKUTA, K. ET AL., BIOCHEMICAL JOURNAL, vol. 388, 2005, pages 555 - 562
M. BODANSZKY, M. A. ONDETTI: "Peptide Synthesis", 1966, INTERSCIENCE PUBLISHERS
SCHROEDER, LUEBKE: "The Peptide", 1965, ACADEMIC PRESS
NATURE, vol. 342, 1989, pages 440
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 163, 1989, pages 967 - 973
PROC. NATL. ACAD. SCI. U.S.A., vol. 88, no. 16, 1991, pages 7001 - 7005
J. SAMBROOK ET AL.: "Molecular Cloning, A laboratory Manual", 2001, COLD SPRING HARBOR LAB. PRESS
"Experimental Medicine", 1996, YODOSHA CO., LTD., article "Idenshi Chiryo No Kiso-gijyutsu"
"Experimental Medicine", 1997, YODOSHA CO., LTD., article "Idenshi Dounyu & Hatsugen Kaiseki Jikken-hou"
"Idenshi Chiryo Kaihatsu Kenkyu Handbook", 1999, NTS INC.
COFFIN, R.S. ET AL., J. GEN. VIROL., vol. 79, 1998, pages 3019 - 3026
PALMER, J. A. ET AL., J. VIROL., vol. 74, 2000, pages 5604 - 5618
LILLEY, C. E. ET AL., J. VIROL., vol. 75, 2001, pages 4343 - 4356
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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