PROMOTER SYSTEM INDUCING EXPRESSION BY 3-HYDROXYPROPIONIC ACID AND METHOD FOR BIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID USING SAME

Title:

PROMOTER SYSTEM INDUCING EXPRESSION BY 3-HYDROXYPROPIONIC ACID AND METHOD FOR BIOLOGICAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID USING SAME

Document Type and Number:

WIPO Patent Application WO/2016/200239

Kind Code:

A1

Abstract:

The present invention relates to a promoter system inducing expression by 3-hydroxypropionic acid and a method for biological production of 3-hydroxypropionic acid using the same. In order to biologically improve 3-HP production, new enzymes having enzymatic activity need to be continuously produced. As a result of screening transcription regulators and promoters reacting with 3-HP from several microorganisms including P. denitrificans, it was verified that the transcription regulators and promoters are composed of the LysR protein and a particular gene nucleotide sequence binding to the protein. Therefore, the 3-HP inducible system according to the present invention is expected to be effectively used in the regulation of a 3-HP metabolic pathway.

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Inventors:

PARK SUNG-HOON (KR)
ZHOU SHENGFANG (KR)
ASHOK SOMASUNDAR (KR)
SEOL EUN HEE (KR)
AINALA SATISH KUMAR (KR)

Application Number:

PCT/KR2016/006261

Publication Date:

December 15, 2016

Filing Date:

June 13, 2016

Export Citation:

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Assignee:

PUSAN NAT UNIV INDUSTRY-UNIV COOP FOUND (KR)

International Classes:

C12N15/78; C12P7/42

Foreign References:

US8883464B2	2014-11-11
KR101437042B1	2014-09-02
JP2013542747A	2013-11-28

Other References:

ZHOU, SHENGFANG ET AL.: "Development of a Deletion Mutant of Pseudomonas Denitrificans that does not degrade 3-Hydroxypropionic Acid", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 98, no. 10, 2014, pages 4389 - 4398, XP035318182
ZHOU, SHENGFANG ET AL.: "Cloning, Expression and Characterization of 3-Hydroxyi sobutyrate Dehydrogenase from Pseudomonas Denitrificans ATCC 13867", PLOS ONE, vol. 8, no. 5, 2013, pages 1 - 11, XP055335516
ZHOU, SHENGFANG ET AL.: "Inducible Gene Expression System by 3-Hydroxypropionic Acid", BIOTECHNOLOGY FOR BIOFUELS, vol. 8, no. 1, January 2015 (2015-01-01), pages 1 - 8, XP021230389
See also references of EP 3321364A4

Attorney, Agent or Firm:

TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)

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