Title:
PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION
Document Type and Number:
WIPO Patent Application WO2000053753
Kind Code:
A3
Abstract:
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Inventors:
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
KUO SOPHIA S (US)
MARK MELANIE R (US)
MARSTERS SCOT A (US)
PAONI NICHOLAS F (US)
PITTI ROBERT M (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
KUO SOPHIA S (US)
MARK MELANIE R (US)
MARSTERS SCOT A (US)
PAONI NICHOLAS F (US)
PITTI ROBERT M (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
Application Number:
PCT/US2000/000219
Publication Date:
April 19, 2001
Filing Date:
January 05, 2000
Export Citation:
Assignee:
GENENTECH INC (US)
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
KUO SOPHIA S (US)
MARK MELANIE R (US)
MARSTERS SCOT A (US)
PAONI NICHOLAS F (US)
PITTI ROBERT M (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
ASHKENAZI AVI J (US)
BAKER KEVIN P (US)
FERRARA NAPOLEONE (US)
GERBER HANSPETER (US)
GODDARD AUDREY (US)
GODOWSKI PAUL J (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
KUO SOPHIA S (US)
MARK MELANIE R (US)
MARSTERS SCOT A (US)
PAONI NICHOLAS F (US)
PITTI ROBERT M (US)
WATANABE COLIN K (US)
WILLIAMS P MICKEY (US)
WOOD WILLIAM I (US)
International Classes:
A61K38/17; C07K14/47; C07K14/705; C07K16/18; C12N15/11; C12N15/12; C12N15/62; C12Q1/68; G01N33/53; A61K38/00; (IPC1-7): C12N15/12; A61K38/17; C07K14/47; C07K16/18; C12N15/11; C12N15/62; C12Q1/68; G01N33/53
Domestic Patent References:
| WO1995029242A1 | 1995-11-02 |
Foreign References:
| EP0861894A1 | 1998-09-02 | |||
| EP0335243A2 | 1989-10-04 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 03 31 March 1999 (1999-03-31)
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